ArticleBMC evolutionary biology2010
Functional bias in molecular evolution rate of Arabidopsis thaliana.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- BLSSpeller to discover novel regulatory motifs in maize.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- cis-prenyltransferase 3 and α/β-hydrolase are new determinants of dolichol accumulation in Arabidopsis.Plant, cell & environment · 2022Article
- Patterns of Population Variation in Two Paleopolyploid Eudicot Lineages Suggest That Dosage-Based Selection on Homeologs Is Long-Lived.Genome biology and evolution · 2018Article
- Functional divergence of duplicate genes several million years after gene duplication in Arabidopsis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Integrating Early Transcriptomic Responses to Rhizotoxins in Rice (Frontiers in plant science · 2017Article
- Evolutionary history of Methyltransferase 1 genes in hexaploid wheat.BMC genomics · 2014Article
- Copy number polymorphism in plant genomes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Review
- The landscape of nucleotide polymorphism among 13,500 genes of the conifer picea glauca, relationships with functions, and comparison with medicago truncatula.Genome biology and evolution · 2013Article
- Contrasting patterns of evolution following whole genome versus tandem duplication events in Populus.Genome research · 2012Article
- CS-AMPPred: an updated SVM model for antimicrobial activity prediction in cysteine-stabilized peptides.PloS one · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCharacteristics derived from mutation and other mechanisms that are advantageous for survival are often preserved during evolution by natural selection. Some genes are conserved in many organisms because they are responsible for fundamental biological function, others are conserved for their unique functional characteristics. Therefore one would expect the rate of molecular evolution for individual genes to be dependent on their biological function. Whether this expectation holds for genes duplicated by whole genome duplication is not known.
resultsWe empirically demonstrate here, using duplicated genes generated from the Arabidopsis thaliana alpha-duplication event, that the rate of molecular evolution of genes duplicated in this event depend on biological function. Using functional clustering based on gene ontology annotation of gene pairs, we show that some duplicated genes, such as defense response genes, are under weaker purifying selection or under stronger diversifying selection than other duplicated genes, such as protein translation genes, as measured by the ratio of nonsynonymous to synonymous divergence (dN/dS).
conclusionsThese results provide empirical evidence indicating that molecular evolution rate for genes duplicated in whole genome duplication, as measured by dN/dS, may depend on biological function, which we characterize using gene ontology annotation. Furthermore, the general approach used here provides a framework for comparative analysis of molecular evolution rate for genes based on their biological function.
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