ArticleBMC neuroscience2010
Steroid receptor expression in the fish inner ear varies with sex, social status, and reproductive state.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 91 citations in OpenAlex.
- Territory proximity influences aggression and modulates the relationship between social dominance and oxidative stress in a highly social African cichlid fish.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in aggression and its neural substrate in a cichlid fish.Scientific reports · 2025Article
- Sex differences in aggression and its neural substrate in a cichlid fish.bioRxiv : the preprint server for biology · 2024Article
- Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Frontiers in neuroendocrinology · 2023Review
- Control of social status by sex steroids: insights from teleost fishes.Molecular psychology : brain, behavior, and society · 2023Article
- Estrogenic Modulation of Retinal Sensitivity in Reproductive Female Túngara Frogs.Integrative and comparative biology · 2021Article
- Environmental Cues and Mechanisms Underpinning Sex Change in Fish.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- Evolutionary divergence of novel open reading frames in cichlids speciation.Scientific reports · 2020Article
- Seasonal regulation of behaviour: what role do hormone receptors play?Proceedings. Biological sciences · 2020Article
- Evaluating testosterone as a phenotypic integrator: From tissues to individuals to species.Molecular and cellular endocrinology · 2019Review
- Hormonal regulation of social ascent and temporal patterns of behavior in an African cichlid.Hormones and behavior · 2019Article
- Sexually-Relevant Visual and Chemosensory Signals Induce Distinct Behaviors and Neural Activation Patterns in the Social African Cichlid,Frontiers in behavioral neuroscience · 2018Article
- ZENK induction in the zebra finch brain by song: Relationship to hemisphere, rhythm, oestradiol and sex.Journal of neuroendocrinology · 2017Article
- GPER/GPR30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (Carassius auratus) and colocalizes with isotocin.The Journal of comparative neurology · 2017Article
- Two types of dominant male cichlid fish: behavioral and hormonal characteristics.Biology open · 2016Article
- Progesterone and prostaglandin F2α induce species-typical female preferences for male sexual displays in Cope's gray treefrog (Hyla chrysoscelis).Physiology & behavior · 2015Article
- Gene expression underlying enhanced, steroid-dependent auditory sensitivity of hair cell epithelium in a vocal fish.BMC genomics · 2015Article
- Social Transitions Cause Rapid Behavioral and Neuroendocrine Changes.Integrative and comparative biology · 2015Review
- Neuroendocrine control of seasonal plasticity in the auditory and vocal systems of fish.Frontiers in neuroendocrinology · 2015Review
- Social status differences regulate the serotonergic system of a cichlid fish, Astatotilapia burtoni.The Journal of experimental biology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGonadal and stress-related steroid hormones are known to influence auditory function across vertebrates but the cellular and molecular mechanisms responsible for steroid-mediated auditory plasticity at the level of the inner ear remain unknown. The presence of steroid receptors in the ear suggests a direct pathway for hormones to act on the peripheral auditory system, but little is known about which receptors are expressed in the ear or whether their expression levels change with internal physiological state or external social cues. We used qRT-PCR to measure mRNA expression levels of multiple steroid receptor subtypes (estrogen receptors: ERalpha, ERbetaa, ERbetab; androgen receptors: ARalpha, ARbeta; corticosteroid receptors: GR2, GR1a/b, MR) and aromatase in the main hearing organ of the inner ear (saccule) in the highly social African cichlid fish Astatotilapia burtoni, and tested whether these receptor levels were correlated with circulating steroid concentrations.
resultsWe show that multiple steroid receptor subtypes are expressed within the main hearing organ of a single vertebrate species, and that expression levels differ between the sexes. We also show that steroid receptor subtype-specific changes in mRNA expression are associated with reproductive phase in females and social status in males. Sex-steroid receptor mRNA levels were negatively correlated with circulating estradiol and androgens in both males and females, suggesting possible ligand down-regulation of receptors in the inner ear. In contrast, saccular changes in corticosteroid receptor mRNA levels were not related to serum cortisol levels. Circulating steroid levels and receptor subtype mRNA levels were not as tightly correlated in males as compared to females, suggesting different regulatory mechanisms between sexes.
conclusionsThis is the most comprehensive study of sex-, social-, and reproductive-related steroid receptor mRNA expression in the peripheral auditory system of any single vertebrate. Our data suggest that changes in steroid receptor mRNA expression in the inner ear could be a regulatory mechanism for physiological state-dependent auditory plasticity across vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.