SynthesisRespiratory research2010
Exhaled carbon monoxide in asthmatics: a meta-analysis.
Synthesis in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Laparoscopic versus open orchiopexy for non-palpable undescended testes in children: a systemic review and meta-analysis.Pediatric surgery international · 2011Pooled it
- High inhaled oxygen concentration quadruples exhaled CO in healthy volunteers monitored by a highly sensitive laser spectrometer.Scientific reports · 2019Trial
- Headset-Type Biofluorometric Gas Sensor with CMOS for Transcutaneous Ethanol from the Ear Canal.Sensors (Basel, Switzerland) · 2026Article
- Exhaled carbon monoxide: variations due to collection method and physiology.Journal of breath research · 2025Article
- Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics.Micromachines · 2023Review
- Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.Journal of clinical medicine research · 2022Article
- Neutrophils and Asthma.Diagnostics (Basel, Switzerland) · 2022Review
- Immune Regulation of Heme Oxygenase-1 in Allergic Airway Inflammation.Antioxidants (Basel, Switzerland) · 2022Review
- Transcutaneous CO-oximetry differentiates asthma exacerbation and convalescence in children.The Journal of allergy and clinical immunology · 2018Observational
- Low Power Operation of Temperature-Modulated Metal Oxide Semiconductor Gas Sensors.Sensors (Basel, Switzerland) · 2018Article
- Carbon monoxide in the treatment of sepsis.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.Pediatric blood & cancer · 2015Article
- Friend or foe? Carbon monoxide and the mitochondria.Frontiers in physiology · 2015Article
- Asthma across the ages: knowledge gaps in childhood asthma.The Journal of allergy and clinical immunology · 2014Review
- Carbon monoxide in exhaled breath testing and therapeutics.Journal of breath research · 2013Review
- Therapeutic applications of carbon monoxide.Oxidative medicine and cellular longevity · 2013Review
- Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations.Nucleic acid therapeutics · 2012Article
- Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.Journal of exposure science & environmental epidemiologyReview
- Nicotine Dependence, Its Risk Indicators, and Exhaled Carbon Monoxide Levels among the Smokers in Bengaluru, India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe non-invasive assessment of airway inflammation is potentially advantageous in asthma management. Exhaled carbon monoxide (eCO) measurement is cheap and has been proposed to reflect airway inflammation and oxidative stress but current data are conflicting. The purpose of this meta-analysis is to determine whether eCO is elevated in asthmatics, is regulated by steroid treatment and reflects disease severity and control.
methodsA systematic search for English language articles published between 1997 and 2009 was performed using Medline, Embase and Cochrane databases. Observational studies comparing eCO in non-smoking asthmatics and healthy subjects or asthmatics before and after steroid treatment were included. Data were independently extracted by two investigators and analyzed to generate weighted mean differences using either a fixed or random effects meta-analysis depending upon the degree of heterogeneity.
results18 studies were included in the meta-analysis. The eCO level was significantly higher in asthmatics as compared to healthy subjects and in intermittent asthma as compared to persistent asthma. However, eCO could not distinguish between steroid-treated asthmatics and steroid-free patients nor separate controlled and partly-controlled asthma from uncontrolled asthma in cross-sectional studies. In contrast, eCO was significantly reduced following a course of corticosteroid treatment.
conclusionseCO is elevated in asthmatics but levels only partially reflect disease severity and control. eCO might be a potentially useful non-invasive biomarker of airway inflammation and oxidative stress in nonsmoking asthmatics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.