ArticleAmyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases2010
Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study.
Article in Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05695521 (Phase 1 Safety Run-in Study and Phase 1b Randomized, Double Blinded, Placebo Controlled Trial), which is not on this map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 1 Safety Run-in Study and Phase 1b Randomized, Double Blinded, Placebo Controlled Trial
Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses.International journal of environmental research and public health · 2018Pooled it
- Epidemiological evidence that physical activity is not a risk factor for ALS.European journal of epidemiology · 2014Pooled it
- Exploring the ALS Multistep Model.Brain sciences · 2026Review
- Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study.Journal of the neurological sciences · 2024Article
- Work-related factors and risk of amyotrophic lateral sclerosis: A multivariable Mendelian randomization study.Brain and behavior · 2023Article
- Raw Water and ALS: A Unifying Hypothesis for the Environmental Agents Involved in ALS.Annals of neurosciences · 2023Review
- Mesenchymal stem cell therapy in amyotrophic lateral sclerosis (ALS) patients: A comprehensive review of disease information and future perspectives.Iranian journal of basic medical sciences · 2023Review
- The toxic metal hypothesis for neurological disorders.Frontiers in neurology · 2023Article
- Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.Acta neurologica Scandinavica · 2022Article
- Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS.Degenerative neurological and neuromuscular disease · 2022Article
- History of vigorous leisure-time physical activity and early onset amyotrophic lateral sclerosis (ALS), data from the national ALS registry: 2010-2018.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2021Article
- The Relationship between Selected Demographic Factors and Speech Organ Dysfunction in Sporadic ALS Patients.Medicina (Kaunas, Lithuania) · 2020Article
- Effects of exercise on sleep in neurodegenerative disease.Neurobiology of disease · 2020Review
- Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group.Journal of neurology · 2020Article
- A Possible Antioxidant Role for Vitamin D in Soccer Players: A Retrospective Analysis of Psychophysical Stress Markers in a Professional Team.International journal of environmental research and public health · 2020Article
- Atlanta metropolitan area amyotrophic lateral sclerosis (ALS) surveillance: incidence and prevalence 2009-2011 and survival characteristics through 2015.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020Article
- Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study.International journal of environmental research and public health · 2020Article
- Intentions of Canadian health professionals towards recommending exercise for people living with ALS.BMC neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Our objective was to investigate exposure to physical exercise and trauma in patients with amyotrophic lateral sclerosis (ALS) compared to the general population. Previous studies in this area have yielded conflicting results. Using population-based ALS registries from Italy, the UK and Ireland, newly diagnosed patients with definite, probable or possible ALS were enrolled in a case- control study with two age- and sex-matched controls for each patient. Source, intensity and duration of physical activity and history of trauma were recorded. We here present the results of a pilot investigation. We studied 61 patients and 112 controls. Forty-one per cent of cases and 17.0% of controls (p = 0.001) had blue-collar occupations; 13.1% versus 3.6% reported strenuous physical activity at work (p = 0.05). Compared with controls, ALS patients had a longer exposure to work-related (10.7 vs. 7.3 years; p = 0.02) and sport-related physical exercise (9.6 vs. 5.2 years; p = 0.005). Three patients (0 controls) reported professional sports (p = 0.04). Traumatic events were similar. Blue collar occupation (OR 4.27; 95% CI 1.68-10.88) and duration of sport-related physical exercise (OR 1.03; 95% CI 1.00-1.05) were independent variables in multivariate analysis. We concluded that ALS is associated with physical exercise but not with traumatic events.
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