ArticleAnalytical chemistry2010
Fluorescent metal nanoshell probe to detect single miRNA in lung cancer cell.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Advances in Lung Cancer Treatment Using Nanomedicines.ACS omega · 2023Review
- Zero→Two-Dimensional Metal Nanostructures: An Overview on Methods of Preparation, Characterization, Properties, and Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Article
- Review
- Application of atomic force microscopy in cancer research.Journal of nanobiotechnology · 2018Review
- Review
- Radiative decay engineering 8: Coupled emission microscopy for lens-free high-throughput fluorescence detection.Analytical biochemistry · 2017Article
- Evaluation of uptake and distribution of gold nanoparticles in solid tumors.European physical journal plus · 2015Article
- Small RNA Detection by in Situ Hybridization Methods.International journal of molecular sciences · 2015Review
- Imaging of Protein Secretion from a Single Cell Using Plasmonic Substrates.BioNanoScience · 2013Article
- Optical imaging of tumor microenvironment.American journal of nuclear medicine and molecular imaging · 2013Article
- Fluorescence Intensity and Lifetime Cell Imaging with Luminescent Gold Nanoclusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2012Article
- Direct quantification of microRNA at low picomolar level in sera of glioma patients using a competitive hybridization followed by amplified voltammetric detection.Analytical chemistry · 2012Article
- Noble metal nanoparticles applications in cancer.Journal of drug delivery · 2012Article
- Noble metal nanoparticles for biosensing applications.Sensors (Basel, Switzerland) · 2012Review
- Target molecule imaging on tissue specimens by fluorescent metal nanoprobes.Journal of biomedical optics · 2011Article
- Fluorescent Metal Nanoshells: Lifetime-Tunable Molecular Probes in Fluorescent Cell Imaging.The journal of physical chemistry. C, Nanomaterials and interfaces · 2011Article
- Detection of CXCR4 receptors on cell surface using a fluorescent metal nanoshell.Journal of biomedical opticsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this study, fluorescent metal nanoshells were synthesized as a molecular imaging agent to detect single microRNA (miRNA) molecules in the cells positive to lung cancer. These metal nanoshells were composed of silica spheres with encapsulated Ru(bpy)(3)(2+) complexes as cores and thin silver layers as shells. Compared with the silica spheres in the absence of metal, the metal nanoshells displayed an enhanced emission intensity, shortened lifetime, and extended photostability. The single-stranded probe oligonucleotides were covalently bound on the metal nanoshells to hybridize with the target miRNA-486 molecules in the cells. It was shown that with stronger emission intensity and longer lifetime, the conjugated metal nanoshells were isolated distinctly from the cellular autofluorescence on the cell images. These emission spots on the cell images were counted accurately and analyzed with a pool of cells representing the miRNA-486 expression levels in the cells. The results may reflect a genomic signal change and provide a reference to lung cancer early diagnosis as well as other diseases.
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Registered trials
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