ArticleEMBO molecular medicine2010
1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma.
Article in EMBO molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
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- Evolution of Repetitive Elements, Their Roles in Homeostasis and Human Disease, and Potential Therapeutic Applications.Biomolecules · 2024Review
- Antipsychotics Affect Satellite III (1q12) Copy Number Variations in the Cultured Human Skin Fibroblasts.International journal of molecular sciences · 2023Article
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- Repeat Element Activation-Driven Inflammation: Role of NFκB and Implications in Normal Development and Cancer?Biomedicines · 2022Review
- The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells.Cells · 2021Review
- Meiotic Nuclear Architecture in Distinct Mole Vole Hybrids with Robertsonian Translocations: Chromosome Chains, Stretched Centromeres, and Distorted Recombination.International journal of molecular sciences · 2020Article
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- Repetitive Fragile Sites: Centromere Satellite DNA As a Source of Genome Instability in Human Diseases.Genes · 2018Review
- Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.Chromosoma · 2018Article
- Genomic complexity of multiple myeloma and its clinical implications.Nature reviews. Clinical oncology · 2017Review
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- MiR-320e is a novel prognostic biomarker in colorectal cancer.British journal of cancer · 2015Article
- Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.PLoS biology · 2014Article
- Genomic characterization of large heterochromatic gaps in the human genome assembly.PLoS computational biology · 2014Article
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- Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation.Nucleic acids research · 2014Article
- Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.The Journal of clinical investigation · 2012Article
- The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.Nature cell biology · 2010Article
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Authors and funding
27 authors at 6 institutions in 1 country.
Funding
Abstract
Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability. Here, we report the first evidence that a distinct category of chromosomal translocations observed in human tumours--those targeting 1q12 satellite DNA--can directly mediate such perturbations by promoting the formation of aberrant heterochromatic foci (aHCF). By detailed investigations of a 1q12 translocation to chromosome 2p, in a case of human B cell lymphoma, aberrant aHCF were shown to be localized to the nuclear periphery and to arise as a consequence of long range 'pairing' between the translocated 1q12 and chromosome 2 centromeric regions. Remarkably, adjacent 2p sequences showed increased levels of repressive histone modifications, including H4K20me3 and H3K9me3, and were bound by HP1. aHCF were associated to aberrant spatial localization and deregulated expression of a novel 2p gene (GMCL1) that was found to have prognostic impact in diffuse large B cell lymphoma. Thus constitutive heterochromatin rearrangements can contribute to tumourigenesis by perturbing gene expression via long range epigenetic mechanisms.
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