ReviewNeurourology and urodynamics2010
Is the urothelium intelligent?
Review in Neurourology and urodynamics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.American journal of physiology. Cell physiology · 2023Article
- The effect of amino acids on the bladder cycle: a concise review.Amino acids · 2022Review
- Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium.Naunyn-Schmiedeberg's archives of pharmacology · 2018Review
- Mathematical modelling of stretch-induced membrane traffic in bladder umbrella cells.Journal of theoretical biology · 2016Article
- Recovery of urothelial mediator release but prolonged elevations in interleukin-8 and nitric oxide secretion following mitomycin C treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Enhanced urothelial ATP release and contraction following intravesical treatment with the cytotoxic drug, doxorubicin.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Neurogenic mechanisms in bladder and bowel ageing.Biogerontology · 2015Review
- Local receptors as novel regulators for peripheral clock expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Luminal DMSO: effects on detrusor and urothelial/lamina propria function.BioMed research international · 2014Article
- ATP during early bladder stretch is important for urgency in detrusor overactivity patients.BioMed research international · 2014Article
- Overactive bladder syndrome and the potential role of prostaglandins and phosphodiesterases: an introduction.Nephro-urology monthly · 2013Review
- At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response.Brain, behavior, and immunity · 2013Review
- From urothelial signalling to experiencing a sensation related to the urinary bladder.Acta physiologica (Oxford, England) · 2013Review
- Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors.BJU international · 2012Article
- Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection.FEMS microbiology reviews · 2012Review
- Coining a new term-Urovesicology: advancing towards a mechanistic understanding of bladder symptoms.Translational andrology and urology · 2012Article
- Defining protein expression in the urothelium: a problem of more than transitional interest.American journal of physiology. Renal physiology · 2011Review
- Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.The FEBS journal · 2011Article
- Intakes of vitamins and minerals in relation to urinary incontinence, voiding, and storage symptoms in women: a cross-sectional analysis from the Boston Area Community Health survey.European urology · 2011Article
- Sophisticated models and methods for studying neurogenic bladder dysfunction.Neurourology and urodynamics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
The urothelium separates the urinary tract lumen from underlying tissues of the tract wall. Previously considered as merely an effective barrier between these two compartments it is now recognized as a more active tissue that senses and transduces information about physical and chemical conditions within the urinary tract, such as luminal pressure, urine composition, etc. To understand this sensory function it is useful to consider the urothelium and suburothelium as a functional unit; containing uroepithelial cells, afferent and efferent nerve fibers and suburothelial interstitial cells. This structure responds to alterations in its external environment through the release of diffusible agents, such as ATP and acetylcholine, and eventually modulates the activity of afferent nerves and underlying smooth muscles. This review considers different stresses the urothelium/suburothelium responds to; the particular chemicals released; the cellular receptors that are consequently affected; and how nerve and muscle function is modulated. Brief consideration is also to regional differences in the urothelium/suburothelium along the urinary tract. The importance of different pathways in relaying sensory information in the normal urinary tract, or whether they are significant only in pathological conditions is also discussed. An operational definition of intelligence is used, whereby a system (urothelium/suburothelium) responds to external changes, to maximize the possibility of the urinary tract achieving its normal function. If so, the urothelium can be regarded as intelligent. The advantage of this approach is that input-output functions can be mathematically formulated, and the importance of different components contributing to abnormal urinary tract function can be calculated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.