ArticleFamilial cancer2010
Knowledge, attitudes, and clinical experience of physicians regarding preimplantation genetic diagnosis for hereditary cancer predisposition syndromes.
Article in Familial cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Fertility desires and outcomes in patients with selected hereditary cancer syndromes.Gynecologic oncology reports · 2026Article
- Neurologists' understanding of reproductive medicine options for genetic forms of motor neuron disease.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025Article
- Review
- Preimplantation genetic testing for monogenic disorders: clinical experience with BRCA1 and BRCA2 from 2010-2021.Journal of assisted reproduction and genetics · 2023Article
- Specialist physicians' referral behavior regarding preimplantation genetic testing for single-gene disorders: Is there room to grow?F&S reports · 2021Article
- Uptake of prenatal diagnostic testing for retinoblastoma compared to other hereditary cancer syndromes in the Netherlands.Familial cancer · 2017Article
- Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.Journal of medical genetics · 2015Review
- "Would you test your children without their consent?" and other sticky dilemmas in the field of cancer genetic testing.Familial cancer · 2014Article
- Preimplantation genetic diagnosis for inherited neurological disorders.Nature reviews. Neurology · 2014Review
- Knowledge and Educational Needs about Pre-Implantation Genetic Diagnosis (PGD) among Oncology Nurses.Journal of clinical medicine · 2014Article
- Comparison of attitudes regarding preimplantation genetic diagnosis among patients with hereditary cancer syndromes.Familial cancer · 2014Article
- More than 10 years after the first 'savior siblings': parental experiences surrounding preimplantation genetic diagnosis.Journal of genetic counseling · 2013Article
- Breast cancer in the young: role of the geneticist.Journal of thoracic disease · 2013Article
- Views of internists towards uses of PGD.Reproductive biomedicine online · 2013Article
- Preimplantation genetic diagnosis for inherited breast cancer: first clinical application and live birth in Spain.Familial cancer · 2012Article
- Attitudes to reproductive genetic testing in women who had a positive BRCA test before having children: a qualitative analysis.European journal of human genetics : EJHG · 2012Article
- Views of preimplantation genetic diagnosis among psychiatrists and neurologists.The Journal of reproductive medicineArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Approximately 5-10% of cancers are caused by an inherited predisposition. Individuals affected by hereditary cancer are often concerned about transmitting a predisposition to cancer to their children. Preimplantation genetic diagnosis (PGD) is a technology that allows embryos without a deleterious mutation associated with a hereditary cancer syndrome to be identified and implanted. The aim of this study is to assess the knowledge, attitudes, and clinical experience of physicians regarding PGD for hereditary cancer predisposition syndromes. Hereditary Breast and Ovarian Cancer (HBOC) and Familial Adenomatous Polyposis (FAP) are two hereditary cancer syndromes highlighted in this present study. A survey assessing physicians' attitudes, knowledge, and clinical practice was completed by a total of 373 gynecologic oncologists (GYN ONCs) and obstetrics and gynecologists (OB/GYNs). Physicians had a limited knowledge of PGD for hereditary cancer; however, physicians reported PGD was an appropriate option for patients with either HBOC or FAP. Although GYN ONCs were more likely to care for patients with hereditary cancer (P < 0.001), they were less likely than OB/GYNs to refer their patients to a PGD specialist (P = 0.004). While 80% of GYN ONCs and 91% of OB/GYNs would refer patients to a PGD specialist, clinical experience indicates that only 29% actually referred their patients. Since 68% of physicians had incorrect or limited knowledge of PGD for hereditary cancer, there is a need for additional education.
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