ArticleNeurochemical research2010
Presynaptic glycine receptors influence plasma membrane potential and glutamate release.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Synaptic vs. Non-Synaptic Glycine Receptors: Physiological Role and Implications in Alzheimer's Disease Pathology.International journal of molecular sciences · 2026Review
- Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus.Biomedicines · 2025Article
- Interactions Involving Glycine and Other Amino Acid Neurotransmitters: Focus on Transporter-Mediated Regulation of Release and Glycine-Glutamate Crosstalk.Biomedicines · 2024Review
- Interactions between Glycine and Glutamate through Activation of Their Transporters in Hippocampal Nerve Terminals.Biomedicines · 2023Article
- Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants.Cellular and molecular life sciences : CMLS · 2022Article
- Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression.Science advances · 2021Article
- High Concentration of Ketone Body β-Hydroxybutyrate Modifies Synaptic Vesicle Cycle and Depolarizes Plasma Membrane of Rat Brain Synaptosomes.Journal of molecular neuroscience : MN · 2020Article
- RNA Editing-Systemic Relevance and Clue to Disease Mechanisms?Frontiers in molecular neuroscience · 2016Review
- Influence of Glucose Deprivation on Membrane Potentials of Plasma Membranes, Mitochondria and Synaptic Vesicles in Rat Brain Synaptosomes.Neurochemical research · 2015Article
- Glycine receptors control the generation of projection neurons in the developing cerebral cortex.Cell death and differentiation · 2014Article
- Changes in neural network homeostasis trigger neuropsychiatric symptoms.The Journal of clinical investigation · 2014Article
- Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes.SpringerPlus · 2014Article
- Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.Frontiers in cellular neuroscience · 2014Review
- Glycine receptors and brain development.Frontiers in cellular neuroscience · 2013Review
- Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.The Journal of physiology · 2012Article
- Targeting of glycine site on NMDA receptor as a possible new strategy for autism treatment.Neurochemical research · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycine is a classical inhibitory neurotransmitter however presynaptic glycine receptors have rather depolarizing action. Reasons for latter phenomenon are unknown. In the present paper we have investigated how glycine influences cytosolic chloride level monitored by fluorescent dye SPQ, membrane potential monitored by fluorescent dye DiSC3(5) and [(14)C]-glutamate release in synaptosomes. We estimated that cytosolic chloride concentration in synaptosomes was about 52 +/- 1 mM. Glycine (1 mM) induced chloride efflux and caused slow plasma membrane depolarization. Chloride efflux was almost completely blocked by 100 microM strychnine whilst glycine-induced depolarization was only partially. We also showed that 1 mM glycine induced [(14)C]-glutamate release via a strychnine-insensitive pathway. Hence we have concluded that glycine was able to induce two independent effects in synaptosomes: (1) Chloride efflux with following depolarization. This efflux was sensitive to strychnine and thereby is probably conducted through glycine-gated ion channels. (2) Glutamate release seems to be mediated by glycine transporters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.