ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Circulating CD34(+) cells are elevated in neonates with respiratory distress syndrome.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Circulating CD34 Positive Cells and Immunological Responses in Extremely Preterm Infants.Journal of blood medicine · 2025Article
- Beyond brain injury biomarkers: chemoattractants and circulating progenitor cells as biomarkers of endogenous rehabilitation effort in preterm neonates with encephalopathy.Frontiers in pediatrics · 2023Article
- Article
- Circulating hematopoietic and endothelial progenitor cells in newborn infants: effects of gestational age, postnatal age and clinical stress in the first 3 weeks of life.Early human development · 2013Article
- Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns.BMC pediatrics · 2012Article
- A therapeutic role for mesenchymal stem cells in acute lung injury independent of hypoxia-induced mitogenic factor.Journal of cellular and molecular medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of the paper was to determine whether circulating stem-progenitor cells were elevated along with its mobilizing cytokines in neonatal respiratory distress syndrome (RDS). SUBJECTS AND
methodsCirculating CD34(+) cells were identified by flow cytometry in 41 RDS in comparison with 20 preterm and 14 term controls without diffuse lung diseases. Plasma concentrations of vascular endothelial growth factor, stromal cell-derived factor-1 (SDF-1) and granulocyte-macrophage colony-stimulating factor were determined by immunochemical assays.
resultsThe number of CD34(+) cells was significantly higher in RDS [25(6-174) cells/microl] than in the preterm controls [15(1-100) cells/microl, P < 0.05]. RDS survivors had higher level of CD34(+) cells than non-survivors (P < 0.05), and low CD34(+) cell level in RDS was correlated with prolonged duration of ventilation (r = -0.396, P < 0.05). Likewise, the CD34(+) cell level was inversely associated with Score for Neonatal Acute Physiology Perinatal Extension II (r = -0.473, P < 0.01) in RDS. Plasma SDF-1 concentration was significantly higher in RDS than in the preterm controls (P < 0.01), and was correlated with the level of CD34(+) cells (r = 0.305, P < 0.01).
conclusionsThe level of circulating CD34(+) cells was elevated in RDS along with an increase of plasma SDF-1, suggesting CD34(+) cells might be involved in reparation of neonatal lung injury.
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Registered trials
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