ArticleNature protocols2010
The learned safety paradigm as a mouse model for neuropsychiatric research.
Article in Nature protocols, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Pavlovian safety learning: An integrative theoretical review.Psychonomic bulletin & review · 2025Review
- Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding.Nature communications · 2023Article
- BDNF haploinsufficiency induces behavioral endophenotypes of schizophrenia in male mice that are rescued by enriched environment.Translational psychiatry · 2021Article
- Juvenile stress facilitates safety learning in male and female high alcohol preferring mice.Behavioural brain research · 2021Article
- Foot shock facilitates reward seeking in an experience-dependent manner.Behavioural brain research · 2021Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- Salient safety conditioning improves novel discrimination learning.Behavioural brain research · 2021Article
- Infralimbic cortex activity is required for the expression but not the acquisition of conditioned safety.Psychopharmacology · 2020Article
- Chronic inhibition of GABA synthesis in the infralimbic cortex facilitates conditioned safety memory and reduces contextual fear.Translational psychiatry · 2020Article
- Corticosterone Treatment and Incubation Time After Contextual Fear Conditioning Synergistically Induce Fear Memory Generalization in Neuropeptide S Receptor-Deficient Mice.Frontiers in neuroscience · 2020Article
- Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear-safety discrimination.British journal of pharmacology · 2019Article
- Cue-dependent safety and fear learning in a discriminative auditory fear conditioning paradigm in the mouse.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- A role for miR-132 in learned safety.Scientific reports · 2019Article
- Sound check, stage design and screen plot - how to increase the comparability of fear conditioning and fear extinction experiments.Psychopharmacology · 2019Review
- Role of the mesolimbic dopamine system in relief learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development.Oncotarget · 2017Article
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
- Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects.Human molecular genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear conditioning is one of the most widely used animal models for studying the neurobiological basis of fear and anxiety states. Conditioned inhibition of fear (or learned safety), however, is a relatively unexplored behavioral paradigm addressing the aspect of regulation of fear, which is central to survival and mental health. Although fear conditioning is achieved by pairing a previously neutral, conditioned stimulus (CS) with an aversive, unconditioned stimulus (US), learned safety training consists of a series of explicitly unpaired CS-US presentations. Animals are trained for 3 d, one session per day, and learn to associate the CS with protection from the impending danger of the aversive events. The entire procedure can be completed within 7 d. The protocol has been successfully used to study the molecular underpinnings of a behavioral intervention for depression. This paradigm complements currently used animal tests in neuropsychiatric research addressing the dysregulation of emotional behaviors in genetic, pharmacological or environmental mouse models of human affective disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.