ArticleJournal of the American Society of Nephrology : JASN2010
XIAP reduces muscle proteolysis induced by CKD.
Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Skeletal muscle atrophy in clinical and preclinical models of chronic kidney disease: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- Pathophysiological mechanisms leading to muscle loss in chronic kidney disease.Nature reviews. Nephrology · 2022Review
- Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease.JCI insight · 2020Article
- Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review.Frontiers in physiology · 2018Article
- MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy.Journal of the American Society of Nephrology : JASN · 2017Article
- Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle.American journal of physiology. Renal physiology · 2017Article
- Extracellular vesicle microRNAs mediate skeletal muscle myogenesis and disease.Biomedical reports · 2016Article
- CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation.Journal of the American Society of Nephrology : JASN · 2016Article
- Low-frequency electrical stimulation attenuates muscle atrophy in CKD--a potential treatment strategy.Journal of the American Society of Nephrology : JASN · 2015Article
- Aging and uremia: Is there cellular and molecular crossover?World journal of nephrology · 2015Review
- Muscle wasting in disease: molecular mechanisms and promising therapies.Nature reviews. Drug discovery · 2015Review
- Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration.PloS one · 2015Article
- A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice.Journal of the American Society of Nephrology : JASN · 2014Article
- In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period.Frontiers in cellular neuroscience · 2014Article
- Muscle wasting from kidney failure-a model for catabolic conditions.The international journal of biochemistry & cell biology · 2013Review
- Inhibition of caspase mediated apoptosis restores muscle function after crush injury in rat skeletal muscle.Apoptosis : an international journal on programmed cell death · 2012Article
- Decreased miR-29 suppresses myogenesis in CKD.Journal of the American Society of Nephrology : JASN · 2011Article
- Elevated levels of uterine anti-apoptotic signaling may activate NFKB and potentially confer resistance to caspase 3-mediated apoptotic cell death during pregnancy in mice.Biology of reproduction · 2011Article
- Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
X-chromosome-linked inhibitor of apoptosis protein (XIAP) is an endogenous caspase inhibitor. Caspase-3 contributes to the muscle wasting associated with chronic kidney disease (CKD) and other systemic illnesses, but whether XIAP modulates muscle wasting in CKD is unknown. Here, overexpression of XIAP in cultured skeletal muscle cells decreased protein degradation induced by serum deprivation, suggesting that caspase-mediated proteolysis contributes to muscle atrophy. We generated transgenic mice that overexpress human XIAP specifically in skeletal muscle (mXIAP) and evaluated muscle protein degradation induced by CKD. mXIAP mice with normal kidney function exhibited mild skeletal muscle hypertrophy. Muscle weights of mXIAP mice with CKD (mXIAP-CKD) were indistinguishable from wild-type mice, suggesting that overexpression of XIAP in skeletal muscle protects from CKD-induced muscle atrophy. The rate of total protein degradation, proteasome chymotrypsin-like activity, and caspase-3-mediated actin cleavage all were lower in muscle isolated from mXIAP-CKD mice compared with wild-type CKD mice. Concomitant with the reduction in overall proteolysis, mRNA levels of ubiquitin, muscle-specific ring finger 1, and atrogin-1/muscle atrophy F-box were lower in mXIAP-CKD mice, suggesting that decreased expression of the ubiquitin-proteasome pathway components may contribute to the protein-sparing effects of XIAP. In summary, these results demonstrate that XIAP inhibits multiple aspects of protein degradation in skeletal muscle during CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.