ArticleJournal of geriatric psychiatry and neurology2010
Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
Article in Journal of geriatric psychiatry and neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Inhibitory Control Deficits in Individuals with Amnestic Mild Cognitive Impairment: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- Noninvasive brain stimulation in Alzheimer's disease: systematic review and perspectives for the future.Experimental gerontology · 2011Pooled it
- In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.Annals of neurology · 2013Trial
- Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment.PloS one · 2012Trial
- External validation and time-stability analysis of STARE, a blood-free quantification tool for irreversible PET tracers.bioRxiv : the preprint server for biology · 2026Article
- Neuromark PET: A multivariate method for estimating whole brain fMRI guided intrinsic networks and connectomes from fMRI and PET data.bioRxiv : the preprint server for biology · 2025Article
- Uncovering the System Vulnerability and Criticality of Human Brain Under Dynamical Neuropathological Events in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Characterizing the propagation pathway of neuropathological events of Alzheimer's disease using harmonic wavelet analysis.Medical image analysis · 2022Article
- Differences in Inhibitory Control and Resting Brain Metabolism between Older Chronic Users of Tetrahydrocannabinol (THC) or Cannabidiol (CBD)-A Pilot Study.Brain sciences · 2022Article
- Article
- Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.International journal of molecular sciences · 2021Review
- Prediction of Subtle Cognitive Decline in Normal Aging: Added Value of Quantitative MRI and PET Imaging.Frontiers in aging neuroscience · 2021Article
- Neurobiologic Rationale for Treatment of Apathy in Alzheimer's Disease With Methylphenidate.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Review
- Spatially Distributed Amyloid-β Reduces Glucose Metabolism in Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2020Article
- DynamicJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Earlier detection of Alzheimer disease using N-fold cross validation approach.Journal of medical systems · 2018Article
- The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Validation of olfactory deficit as a biomarker of Alzheimer disease.Neurology. Clinical practice · 2017Article
- Prediction of Mild Cognitive Impairment Conversion Using a Combination of Independent Component Analysis and the Cox Model.Frontiers in human neuroscience · 2017Article
- Utility of Molecular and Structural Brain Imaging to Predict Progression from Mild Cognitive Impairment to Dementia.Journal of Alzheimer's disease : JAD · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Amyloid load in the brain using Pittsburgh compound B ((11)C-PIB) positron emission tomography (PET) and cerebral glucose metabolism using fluorodeoxyglucose ((18)F-FDG) PET were evaluated in patients with mild Alzheimer disease (AD, n = 18), mild cognitive impairment (MCI, n = 24), and controls (CTR, n = 18). ( 11)C-PIB binding potential (BP(ND)) was higher in prefrontal cortex, cingulate, parietal cortex, and precuneus in AD compared to CTR or MCI and in prefrontal cortex for MCI compared to CTR. For (18)F-FDG, regional cerebral metabolic rate for glucose (rCMRGlu) was decreased in precuneus and parietal cortex in AD compared to CTR and MCI, with no MCI-CTR differences. For the AD-CTR comparison, precuneus BP(ND) area under the receiver operating characteristic (ROC) curve (AUC) was 0.938 and parietal cortex rCMRGlu AUC was 0.915; for the combination, AUC was 0.989. ( 11)C-PIB PET BP(ND) clearly distinguished diagnostic groups and combined with (18)F-FDG PET rCMRGlu, this effect was stronger. These PET techniques provide complementary information in strongly distinguishing diagnostic groups in cross-sectional comparisons that need testing in longitudinal studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.