ArticleClinical journal of the American Society of Nephrology : CJASN2010
Relapsing peritonitis in children who undergo chronic peritoneal dialysis: a prospective study of the international pediatric peritonitis registry.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Best Practice of Peritoneal Dialysis-Associated Gram-Negative Peritonitis in Children: Insights From the International Pediatric Peritoneal Dialysis Network Registry.Kidney international reports · 2024Article
- Persistent peritonitis in peritoneal dialysis: a comphrenesive review of recurrent, relapsing, refractory, and repeat peritonitis.International urology and nephrology · 2024Review
- Omentectomy reduces the need for peritoneal dialysis catheter revision in children: a study from the Pediatric Nephrology Research Consortium.Pediatric nephrology (Berlin, Germany) · 2021Article
- Factors associated with length of hospital stay among dialysis patients with nontraumatic acute abdomen: a retrospective observational study.Singapore medical journal · 2020Observational
- Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis.BMC pediatrics · 2020Article
- Peritoneal dialysis catheter placement, outcomes and complications.Pediatric surgery international · 2018Article
- A Clinical Risk Prediction Tool for Peritonitis-Associated Treatment Failure in Peritoneal Dialysis Patients.Scientific reports · 2018Article
- ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2016Review
- Difficult peritonitis cases in children undergoing chronic peritoneal dialysis: relapsing, repeat, recurrent and zoonotic episodes.Pediatric nephrology (Berlin, Germany) · 2015Review
- Chronic peritoneal dialysis in children.International journal of nephrology and renovascular disease · 2015Review
- Readmission within 30 days of hospital discharge among children receiving chronic dialysis.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Surgical outcomes analysis of pediatric peritoneal dialysis catheter function in a rural region.Journal of pediatric surgery · 2013Article
- Peritoneal dialysis associated infections: An update on diagnosis and management.World journal of nephrology · 2012Review
- Consensus guidelines for the prevention and treatment of catheter-related infections and peritonitis in pediatric patients receiving peritoneal dialysis: 2012 update.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2012Review
- Clinical characteristics and outcomes of "silent" and "non-silent" peritonitis in patients on peritoneal dialysis.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisArticle
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Authors and funding
16 authors at 14 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe International Pediatric Peritonitis Registry (IPPR) was established to collect prospective data regarding peritoneal dialysis (PD)-associated peritonitis in children. In this report, we present the IPPR results that pertain to relapsing peritonitis (RP). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was an online, prospective entry into the IPPR of data that pertain to peritonitis cases by participating centers.
resultsOf 490 episodes of nonfungal peritonitis, 52 (11%) were followed by a relapse. There was no significant difference between RP and non-RP in distribution of causative organisms and antibiotic sensitivities. Initial empiric therapy-ceftazidime with either first-generation cephalosporin or glycopeptide (vancomycin or teicoplanin)-was not associated with relapse. Switching to monotherapy with a first-generation cephalosporin on the basis of culture results was associated with higher relapse rate (23%) than other final antibiotic therapies (0 to 9%). Culture-negative RP was less likely to have a satisfactory early treatment response than non-RP (82 versus 98%). Young age, single-cuff catheter, downward-pointing exit site, and chronic systemic antibiotic prophylaxis were additional independent risk factors for RP in the multivariate analysis. Compared with non-RP, RP was associated with a lower rate of full functional recovery (73 versus 91%), higher ultrafiltration problems (14 versus 2%), and higher rate of permanent PD discontinuation (17 versus 7%).
conclusionsThis is the largest multicenter, prospective study to date to examine RP in children. In addition, this is the first report in the literature to examine specifically the relationship of postempiric antibiotic treatment regimens to the subsequent risk for relapse.
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