Evidence map›Paper›PMID 20430870›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2010

Recent advances in the regulation of cholangiocarcinoma growth.

Heather Francis, Gianfranco Alpini, Sharon DeMorrow

Abstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer.Frontiers in cell and developmental biology · 2021
    Review
  2. Article
  3. Cholangiocarcinoma: New InsightsAsian Pacific journal of cancer prevention : APJCP · 2017
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Bile acid signaling and biliary functions.Acta pharmaceutica Sinica. B · 2015
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Innate immune cells in liver inflammation.Mediators of inflammation · 2012
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Heather FrancisDeptartment of Internal Medicine, Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA.
Gianfranco Alpini
Sharon DeMorrow
Texas A&M Health Science Center · US

Funding

GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8M
Role of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8M
TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISR01DK058411 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CHERTOW, GLENN MATTHEW · 2001 to 2003
$1.8M
Endocannabinoid Regulation of Cholangiocarcinoma Cell GrowthK01DK078532 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DEMORROW, SHARON · 2007 to 2011
$697k
The Role of Progranulin in Cholangiocarcinoma GrowthR03DK088012 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DEMORROW, SHARON · 2010 to 2011
$134k
NIDDK NIH HHS DK07698NIDDK NIH HHS DK58411NIDDK NIH HHS K01 DK078532NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R03 DK088012
6 · The paper itself

Abstract

Cholangiocarcinomas arise after the neoplastic transformation of the cholangiocytes that line the intra- and extrahepatic biliary epithelium. Symptoms usually do not present until late in the course of the disease, at which time they are relatively resistant to chemotherapeutic agents and as such are difficult to treat and display a poor prognosis. Because of the relative rarity of this disease, the overall volume of research into the molecular pathophysiology associated with this disease is small compared with other more prevalent tumors. However, the incidence of this devastating cancer is on the rise and renewed efforts to understand the pathogenesis of cholangiocarcinoma is needed to design novel therapeutic strategies to combat this disease. This review summarizes the recent advances into our knowledge and understanding of cholangiocarcinoma and highlights potential novel therapeutic strategies that may prove useful to treat this deadly disease.

Indexed as

Cell ProliferationAnimalsBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaGastrointestinal HormonesHumansInflammation MediatorsIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsRisk FactorsSignal TransductionTumor BurdenGastrointestinal HormonesInflammation MediatorsIntercellular Signaling Peptides and ProteinsNerve Tissue Proteins

Identifiers

PMID20430870
PMCPMC2904122
OpenAlexW2172149175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.