ArticleSocial science & medicine (1982)2010
Life course socioeconomic position is associated with inflammatory markers: the Framingham Offspring Study.
Article in Social science & medicine (1982), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis.Journal of epidemiology and community health · 2017Pooled it
- Systematic review of the evidence of a relationship between chronic psychosocial stress and C-reactive protein.Molecular diagnosis & therapy · 2013Pooled it
- Trial
- Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.Scientific reports · 2016Trial
- Does sex moderate health and Alzheimer's disease risk tied to early educational experiences? The reducing inequities through social and educational change follow-up in early adulthood extension study protocol.Brain, behavior, & immunity - health · 2026Article
- Childhood adversity and spontaneous abortion in a North American preconception cohort study.American journal of epidemiology · 2026Article
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025Review
- The Longitudinal Relationship between Educational Level and Arterial Stiffness: The Toon Health Study.Journal of atherosclerosis and thrombosis · 2025Article
- Intergenerational mobility, race, and allostatic load: Diminished health returns for Black older adults?SSM - population health · 2025Article
- The impact of social determinants of health on chronic kidney disease risk: evidence from the CHARLS study.Frontiers in public health · 2025Article
- "Hang Ups, Let Downs, Bad Breaks, Setbacks": Impact of Structural Socioeconomic Racism and Resilience on Cognitive Change Over Time for Persons Racialized as Black.Health equity · 2024Article
- The association between material-psychological-behavioral framework of financial hardship and markers of inflammation: a cross-sectional study of the Midlife in the United States (MIDUS) Refresher cohort.BMC public health · 2023Article
- Parental education and epigenetic aging in middle-aged and older adults in the United States: A life course perspective.Social science & medicine (1982) · 2023Article
- Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses.Brain, behavior, and immunity · 2023Article
- Systemic Inflammation Contributes to the Association Between Childhood Socioeconomic Disadvantage and Midlife Cardiometabolic Risk.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer.Epigenetics · 2022Article
- Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation.Brain, behavior, and immunity · 2022Article
- Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.Mindfulness · 2022Article
- Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.Obstetric medicine · 2022Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Associations between life course socioeconomic position (SEP) and novel biological risk markers for coronary heart disease such as inflammatory markers are not well understood. Most studies demonstrate inverse associations of life course SEP with C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen, however little is known about associations between life course SEP and other inflammatory markers including intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor II (TNFR2), lipoprotein phospholipase A2 (Lp-PLA2) activity, monocyte chemoattractant protein-1 (MCP-1) or P-selectin. The objectives of this analysis were to determine whether three life course SEP frameworks ("accumulation of risk", "social mobility" and "sensitive periods") are associated with the aforementioned inflammatory markers. We examined 1413 Framingham Offspring Study participants (mean age 61.2+/-8.6 years, 54% women), using multivariable regression analyses. In age- and sex-adjusted regression analyses, cumulative SEP ("accumulation of risk" SEP framework), for low vs. high SEP, was inversely associated with CRP, IL-6, ICAM-1, TNFR2, Lp-PLA2 activity, MCP-1 and fibrinogen. We found that there were few consistent trends between social mobility trajectories and most inflammatory markers. Own educational attainment was inversely associated with 7 of 8 studied inflammatory markers, while father's education, father's occupation and own occupation were inversely associated with 4, 5 and 4 inflammatory markers, respectively, in age- and sex-adjusted analyses. The strengths of association between SEP and inflammatory markers were typically substantially accounted for by CHD risk markers (smoking, body mass index, systolic blood pressure, total:HDL cholesterol ratio, fasting glucose, medications, depressive symptomatology) suggesting these may be important mechanisms that explain associations between SEP and the studied inflammatory markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.