ArticleJournal of neuroimmunology2010
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.
Article in Journal of neuroimmunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analyses of genome-wide association studies identify novel loci influencing Japanese white matter hyperintensities.Journal of human genetics · 2026Pooled it
- The Factors Associated with the Blood-Brain Barrier Dysfunction in Tick-Borne Encephalitis.International journal of molecular sciences · 2025Article
- IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis.Journal of clinical medicine · 2021Article
- Interleukin-15 enhances proinflammatory T-cell responses in patients with MS and EAE.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Astrocytic Interleukin-15 Reduces Pathology of Neuromyelitis Optica in Mice.Frontiers in immunology · 2018Article
- Identification of Relationships Between Interleukin 15 mRNA and Brain-Derived Neurotrophic Factor II mRNA Levels With Formal Components of Temperament in Asthmatic Patients.Molecular neurobiology · 2017Article
- An activation-induced IL-15 isoform is a natural antagonist for IL-15 function.Scientific reports · 2016Article
- Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway.Scientific reports · 2016Article
- A standardized and reproducible protocol for serum-free monolayer culturing of primary paediatric brain tumours to be utilized for therapeutic assays.Scientific reports · 2015Article
- Transcript analysis of laser capture microdissected white matter astrocytes and higher phenol sulfotransferase 1A1 expression during autoimmune neuroinflammation.Journal of neuroinflammation · 2015Article
- Inhibition of phosphoinositide 3-kinase delta attenuates experimental autoimmune encephalomyelitis in mice.International journal of clinical and experimental medicine · 2015Article
- Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system.Frontiers in microbiology · 2015Article
- Protective effect of myokine IL-15 against H2O2-mediated oxidative stress in skeletal muscle cells.Molecular biology reports · 2014Article
- Astragalosides from Radix Astragali benefits experimental autoimmune encephalomyelitis in C57BL /6 mice at multiple levels.BMC complementary and alternative medicine · 2014Article
- Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.Brain, behavior, and immunity · 2014Article
- Leukocyte infiltration across the blood-spinal cord barrier is modulated by sleep fragmentation in mice with experimental autoimmune encephalomyelitis.Fluids and barriers of the CNS · 2014Article
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.Brain, behavior, and immunity · 2013Article
- Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy.Fluids and barriers of the CNS · 2013Article
- Saturable leptin transport across the BBB persists in EAE mice.Journal of molecular neuroscience : MN · 2013Article
- Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells.The Journal of clinical investigation · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin (IL)-15 can cross the blood-brain barrier to act on its specific brain receptor (IL15Ralpha) and co-receptors. The important roles of neuronal IL15 and IL15Ralpha in experimental autoimmune encephalomeylitis (EAE) are suggested by the upregulation of IL15Ralpha mRNA in different regions of the brain and spinal cord, and by double-labeling immunohistochemistry showing neuronal localization of IL15 and IL15Ralpha in different neurons. Contrary to expectations, IL15 treatment lessened EAE severity. IL15 knockout mice showed heightened susceptibility to EAE with significantly higher scores that were decreased by treatment with IL15. Thus, IL15 improves this CNS autoimmune disorder as a potential therapeutic agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.