ArticleThe Journal of allergy and clinical immunology2010
Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Prevalence and risk of viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease: a meta-analysis.Molecular biology reports · 2014Pooled it
- Pulmonary biomarkers in COPD exacerbations: a systematic review.Respiratory research · 2013Pooled it
- Interferon-γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model.The EMBO journal · 2026Article
- Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions.Frontiers in allergy · 2024Review
- The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease.Acta biochimica et biophysica Sinica · 2022Review
- From Biomarkers to Novel Therapeutic Approaches in Chronic Obstructive Pulmonary Disease.Biomedicines · 2021Review
- Impact of a Positive Viral Polymerase Chain Reaction on Outcomes of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations.International journal of environmental research and public health · 2020Article
- Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations.Clinics in chest medicine · 2020Review
- Airway Mycosis and the Regulation of Type 2 Immunity.Journal of fungi (Basel, Switzerland) · 2020Review
- Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium.Frontiers in cell and developmental biology · 2020Review
- Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium.Frontiers in cell and developmental biology · 2020Article
- Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1/Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Mir-29b mediates the regulation of Nrf2 on airway epithelial remodeling and Th1/Th2 differentiation in COPD rats.Saudi journal of biological sciences · 2019Article
- Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.Clinical science (London, England : 1979) · 2019Article
- Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Analysis of viral infection and biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease.The clinical respiratory journal · 2018Article
- Dysregulated Functions of Lung Macrophage Populations in COPD.Journal of immunology research · 2018Review
- The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD.Respirology (Carlton, Vic.) · 2017Review
- The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease.Physiological reviews · 2017Review
- Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis.F1000Research · 2017Review
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Authors and funding
18 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundTobacco-related lung diseases, including chronic obstructive pulmonary disease (COPD), are major causes of lung-related disability and death worldwide. Acute exacerbation of COPD (AE-COPD) is commonly associated with upper and lower respiratory tract viral infections and can result in respiratory failure in those with advanced lung disease.
objectiveWe sought to determine the mechanism underlying COPD exacerbation and host response to pathogen-derived factors.
methodsOver a 24-month period, we assessed the viral causes for upper and lower respiratory tract infections in patients with COPD (n = 155) and control subjects (n = 103). We collected nasal and bronchoalveolar lavage fluid and peripheral blood under baseline and exacerbated conditions. We determined the effect of human rhinovirus (HRV) proteinases on T-cell activation in human subjects and mice.
resultsHRVs are isolated from nasal and lung fluid from subjects with AE-COPD. Bronchoalveolar lavage fluid and CD4 T cells from patients with COPD exhibited a T(H)1 and T(H)2 cell cytokine phenotype during acute infection. HRV-encoded proteinase 2A activated monocyte-derived dendritic cells in vitro and induced strong T(H)1 and T(H)2 immune responses from CD4 T cells. Intranasal administration of recombinant rhinovirus proteinase 2A in mice resulted in an increase in airway hyperreactivity, lung inflammation, and IL-4 and IFN-gamma production from CD4 T cells.
conclusionOur findings suggest that patients with severe COPD show T(H)1- and T(H)2-biased responses during AE-COPD. HRV-encoded proteinase 2A, like other microbial proteinases, could provide a T(H)1- and T(H)2-biasing adjuvant factor during upper and lower respiratory tract infection in patients with severe COPD. Alteration of the immune response to secreted viral proteinases might contribute to worsening of dyspnea and respiratory failure in patients with COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.