ArticleHearing research2011
Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?
Article in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- Sound perception and its effects in plants and algae.Plant signaling & behavior · 2020Review
- Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity.Biophysical journal · 2020Article
- Article
- Reticular lamina and basilar membrane vibrations in living mouse cochleae.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Active amplification in insect ears: mechanics, models and molecules.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Vibration of the organ of Corti within the cochlear apex in mice.Journal of neurophysiology · 2014Article
- Recovery of otoacoustic emissions after high-level noise exposure in the American bullfrog.The Journal of experimental biology · 2014Article
- Modelling cochlear mechanics.BioMed research international · 2014Review
- Faster than the speed of hearing: nanomechanical force probes enable the electromechanical observation of cochlear hair cells.Nano letters · 2012Article
- Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model.Biophysical journal · 2011Article
- Feed-forward and feed-backward amplification model from cochlear cytoarchitecture: an interspecies comparison.Biophysical journal · 2011Article
- Molecular biology of hearing.GMS current topics in otorhinolaryngology, head and neck surgery · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hearing organs have evolved to detect sounds across several orders of magnitude of both intensity and frequency. Detection limits are at the atomic level despite the energy associated with sound being limited thermodynamically. Several mechanisms have evolved to account for the remarkable frequency selectivity, dynamic range, and sensitivity of these various hearing organs, together termed the active process or cochlear amplifier. Similarities between hearing organs of disparate species provides insight into the factors driving the development of the cochlear amplifier. These properties include: a tonotopic map, the emergence of a two hair cell system, the separation of efferent and afferent innervations, the role of the tectorial membrane, and the shift from intrinsic tuning and amplification to a more end organ driven process. Two major contributors to the active process are hair bundle mechanics and outer hair cell electromotility, the former present in all hair cell organs tested, the latter only present in mammalian cochlear outer hair cells. Both of these processes have advantages and disadvantages, and how these processes interact to generate the active process in the mammalian system is highly disputed. A hypothesis is put forth suggesting that hair bundle mechanics provides amplification and filtering in most hair cells, while in mammalian cochlea, outer hair cell motility provides the amplification on a cycle by cycle basis driven by the hair bundle that provides frequency selectivity (in concert with the tectorial membrane) and compressive nonlinearity. Separating components of the active process may provide additional sites for regulation of this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.