ArticleBMC infectious diseases2010
Risk of latent TB infection in individuals employed in the healthcare sector in Germany: a multicentre prevalence study.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Tuberculosis infection status and risk factors among health workers: an updated systematic review.Annals of occupational and environmental medicine · 2021Review
- Tuberculosis Infection Screening in 5468 Italian Healthcare Students: Investigation of a Borderline Zone Value for the QFT-Test.International journal of environmental research and public health · 2020Article
- The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia.Journal of multidisciplinary healthcare · 2020Article
- Hot and Cold Spot Areas of Household Tuberculosis Transmission in Southern China: Effects of Socio-Economic Status andInternational journal of environmental research and public health · 2019Article
- Latent Tuberculosis Infection among Healthcare Workers in Duhok Province: From Screening to Prophylactic Treatment.Tropical medicine and infectious disease · 2019Article
- Isolation measures and protection awareness are significant for latent tuberculosis infection: a cross-sectional study based on T-SPOT.TB among health care workers in China.Epidemiology and infection · 2019Article
- Risk factors of latent tuberculosis infection and immune function in health care workers in Suzhou, China.Journal of thoracic disease · 2018Article
- Health care workers' knowledge, attitudes and practices on tuberculosis infection control, Nepal.BMC infectious diseases · 2017Article
- Article
- Predictors of low prevalence of latent tuberculosis infection among Egyptian health care workers at intensive care and bronchoscopy units.GMS hygiene and infection control · 2016Article
- Prevalence of latent tuberculosis infection in healthcare workers at a hospital in Naples, Italy, a low-incidence country.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Latent tuberculosis infection among a large cohort of medical students at a teaching hospital in Italy.BioMed research international · 2015Article
- IGRA-positive patients and interferon-gamma/interleukin-2 signatures: can the Fluorospot assay provide further information?Infection · 2014Article
- Tuberculosis in healthcare workers - a narrative review from a German perspective.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Tuberculosis screening at the Sainte-Anne Hospital in Paris - results of first and second IGRA.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Occupational screening for tuberculosis and the use of a borderline zone for interpretation of the IGRA in German healthcare workers.PloS one · 2014Article
- Latent tuberculosis infection and associated risk factors among undergraduate healthcare students in Italy: a cross-sectional study.BMC infectious diseases · 2013Article
- Screening for latent tuberculosis in Norwegian health care workers: high frequency of discordant tuberculin skin test positive and interferon-gamma release assay negative results.BMC public health · 2013Article
- Screening for tuberculosis and the use of a borderline zone for the interpretation of the interferon-γ release assay (IGRA) in Portuguese healthcare workers.Journal of occupational medicine and toxicology (London, England) · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealthcare workers are still recognised as a high-risk group for latent TB infection (LTBI). Therefore, the screening of people employed in the healthcare sector for active and LTBI is fundamental to infection control programmes in German hospitals. It was the aim of the study to determine the prevalence and putative risk factors of LTBI.
methodsWe tested 2028 employees in the healthcare sector with the QuantiFERON-Gold In-tube (QFT-IT) test between December 2005 and May 2009, either in the course of contact tracing or in serial testing of TB high-risk groups following German OSH legislation.
resultsA positive IGRA was found in 9.9% of the healthcare workers (HCWs). Nurses and physicians showed similar prevalence rates (9.7% to 9.6%). Analysed by occupational group, the highest prevalence was found in administration staff and ancillary nursing staff (17.4% and 16.7%). None of the individuals in the trainee group showed a positive IGRA result. In the different workplaces the observed prevalence was 14.7% in administration, 12.0% in geriatric care, 14.2% in technicians (radiology, laboratory and pathology), 6.5% in admission ward staff and 8.3% in the staff of pulmonary/infectious disease wards. Putative risk factors for LTBI were age (>55 years: OR14.7, 95% CI 5.1-42.1), being foreign-born (OR 1.99, 95% CI 1.4-2.8), TB in the individual's own history (OR 4.96, 95% CI 1.99-12.3) and previous positive TST results (OR 3.5, 95% CI 2.4-4.98). We observed no statistically significant association with gender, BCG vaccination, workplace or profession.
conclusionThe prevalence of LTBI in low-incidence countries depends on age. We found no positive IGRA results among trainees in the healthcare sector. Incidence studies are needed to assess the infection risk. Pre-employment screening might be helpful in this endeavour.
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