ReviewCritical reviews in biochemistry and molecular biology2010
RecQ4: the second replicative helicase?
Review in Critical reviews in biochemistry and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.Nature communications · 2024Article
- The Genetic and Physical Interactomes of theG3 (Bethesda, Md.) · 2020Article
- Overexpression of RECQL4 is associated with poor prognosis in patients with gastric cancer.Oncology letters · 2018Article
- Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.Nucleic acids research · 2017Article
- Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.The Journal of biological chemistry · 2017Article
- Telomere-associated aging disorders.Ageing research reviews · 2017Review
- CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans.The Journal of cell biology · 2014Article
- Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.Cell reports · 2014Article
- Helicase activation and establishment of replication forks at chromosomal origins of replication.Cold Spring Harbor perspectives in biology · 2013Review
- Archaeology of eukaryotic DNA replication.Cold Spring Harbor perspectives in biology · 2013Review
- On BLM helicase in recombination-mediated telomere maintenance.Molecular biology reports · 2013Article
- The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients.Aging · 2012Article
- RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.Biochimica et biophysica acta · 2012Article
- Article
- RecQ helicases; at the crossroad of genome replication, repair, and recombination.Molecular biology reports · 2012Review
- Review
- Helicase-inactivating mutations as a basis for dominant negative phenotypes.Cell cycle (Georgetown, Tex.) · 2010Review
- Disease-causing missense mutations in human DNA helicase disorders.Mutation researchReview
- Roles of DNA helicases in the maintenance of genome integrity.Molecular & cellular oncologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent work has greatly contributed to the understanding of the biology and biochemistry of RecQ4. It plays an essential non-enzymatic role in the formation of the CMG complex, and thus replication initiation, by means of its Sld2 homologous domain. The helicase domain of RecQ4 has now been demonstrated to possess 3'-5' DNA helicase activity, like the other members of the RecQ family. The biological purpose of this activity is still unclear, but helicase-dead mutants are unable to restore viability in the absence of wildtype RecQ4. This indicates that RecQ4 performs a second role, which requires helicase activity and is implicated in replication and DNA repair. Thus, it is clear that two helicases, RecQ4 and Mcm2-7, are integral to replication. The nature of the simultaneous involvement of these two helicases remains to be determined, and possible models will be proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.