ReviewAdvances in experimental medicine and biology2009
The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer.
Review in Advances in experimental medicine and biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Climate Change, Epigenetics, Microbiota, and Health.International journal of environmental research and public health · 2026Review
- Evaluation ofCurrent protein & peptide science · 2026Article
- Exploring the Immunomodulatory Role of Forkhead Box Protein 3 (FOXP3) in the Pathophysiology of Neuropsychiatric Disorders.Molecular neurobiology · 2025Review
- Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients.Biomedicines · 2024Article
- The TRIM21-FOXD1-BCL-2 axis underlies hyperglycaemic cell death and diabetic tissue damage.Cell death & disease · 2023Article
- Antimicrobial Biomaterials for Chronic Wound Care.Pharmaceutics · 2023Review
- Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancer.Cancer medicine · 2023Article
- Article
- ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin.Nature biotechnology · 2021Article
- Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability.Frontiers in cellular and infection microbiology · 2021Review
- FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway.Frontiers in oncology · 2020Article
- What's Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses.Frontiers in immunology · 2020Review
- Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.Scientific reports · 2019Article
- The transcription factor NFIL3 controls regulatory T-cell function and stability.Experimental & molecular medicine · 2019Article
- The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis.Molecular cancer · 2019Review
- A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy.Journal of oncology · 2019Review
- Transcriptional Profiles of California Sea Lion Peripheral NK and CDFrontiers in immunology · 2019Article
- The Sources of Essential Fatty Acids for Allergic and Cancer Patients; a Connection with Insight into Mammalian Target of Rapamycin: A Narrative ReviewAsian Pacific journal of cancer prevention : APJCP · 2018Review
- Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFMediators of inflammation · 2017Review
- Fox transcription factors: from development to disease.Development (Cambridge, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Transcription factor FoxP3 belongs to the forkhead/winged-helix family of transcriptional regulators and shares general structural features with other FoxP family members. FoxP3 functions as a master of transcription for the development of regulatory T-cells (Treg cells) both in humans and in mice. Natural genetic mutations ofFoxP3 that disrupt its function in humans result in an autoimmune syndrome called Immune Polyendocrinopathy, Enteropathy, X-linked (IPEX) and in mice, its deletion causes the Scurfy phenotype, with similar pathology. The finding that FoxP3 is required for the development and function of Tregs has led to an explosion of research in determining its regulation and function in the immune system. Understanding the biological properties of FoxP3 has a wide range of implications for immune tolerance, autoimmune disorders, inflammation and immune response to infectious diseases and cancer.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.