ArticleJournal of molecular neuroscience : MN2010
VIP and PACAP effects on mouse major pelvic ganglia neurons.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Dissection of Pelvic Autonomic Ganglia and Associated Nerves in Male and Female Rats.Journal of visualized experiments : JoVE · 2020Article
- VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism.Oncogene · 2019Article
- PAC₁ receptors mediate positive chronotropic responses to PACAP-27 and VIP in isolated mouse atria.European journal of pharmacology · 2013Article
- Synaptic transmission at parasympathetic neurons of the major pelvic ganglion from normal and diabetic male mice.Journal of neurophysiology · 2013Article
- Galanin expression in the mouse major pelvic ganglia during explant culture and following cavernous nerve transection.Journal of molecular neuroscience : MN · 2012Article
- Autonomic dysfunction and plasticity in micturition reflexes in human α-synuclein mice.Developmental neurobiology · 2012Article
- A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.Frontiers in neuroscience · 2012Article
- Neuropeptides in lower urinary tract function.Handbook of experimental pharmacology · 2011Review
- PACAP expression in explant cultured mouse major pelvic ganglia.Journal of molecular neuroscience : MN · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Major pelvic ganglia (MPG) neurons innervate urogenital organs and components of the lower bowel. Immunoreactivity for vasoactive intestinal polypeptide (VIP) has previously been observed in the MPG, and VIP knockout animals have impaired micturition reflexes suggesting a role for this neuropeptide in urogenital function. Here, we investigate the presence and action of VIP and a related neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), in the pelvic ganglia of male mice. An abundance of VIP-immunoreactive (IR) neurons and nerve fibers were observed in the ganglion, whereas PACAP immunoreactivity was not seen. Extracts from acutely isolated MPG contained transcripts for the VPAC1, VPAC2, and PAC1 receptors. Local application of VIP, PACAP, or maxadilan to isolated pelvic ganglion neurons shortened the duration of the afterhyperpolarization (AHP) of action potentials elicited by brief intracellular depolarization. All three peptides also increased neuronal excitability within a subpopulation of the sampled neurons. Bath application of apamin, a peptide antagonist of SK channels, shortened the duration of the AHP indicating that AHP duration in pelvic neurons is determined principally by SK-channel activity. The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PAC1 receptors can modulate the activity of the autonomic neurons innervating pelvic organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.