ArticleCellular & molecular biology letters2010
12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis.
Article in Cellular & molecular biology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- The inhibition of PLCγ1 protects chondrocytes against osteoarthritis, implicating its binding to Akt.Oncotarget · 2018Article
- Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1.Scientific reports · 2016Article
- Prion protein and its role in signal transduction.Cellular & molecular biology letters · 2013Review
- 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway.Cellular & molecular biology letters · 2011Article
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2 authors at 1 institution in 1 country.
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Abstract
The PKB signaling pathway is essential for cell survival and the inhibition of apoptosis, but its functional mechanisms have not been fully explored. Previously, we reported that TPA effectively inhibited PKB activity and caused PKB degradation, which was correlated with the repression of PKB phosphorylation at Ser473. In this study, we focus on how PKB is regulated by TPA in gastric cancer cells. One of the TPA targets, PKCalpha, was found to mediate the inhibition of PKB phosphorylation and degredation caused by TPA. Furthermore, TPA induced the import of PKCalpha into the nucleus, where PKCalpha exerted an inhibitory effect on PKB expression and phosphorylation. As a result, cancer cell proliferation was arrested. Our study characterizes a novel function of PKCalpha in mediating the negative regulation of PKB by TPA, and suggests a potential application in the clinical treatment of gastric cancer.
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