ArticleDigestive diseases and sciences2010
Incidence and risk of intestinal and extra-intestinal complications in Medicaid patients with inflammatory bowel disease: a 5-year population-based study.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Increased Lifetime Risk of Intestinal Complications and Extraintestinal Manifestations in Crohn's Disease and Ulcerative Colitis.Gastroenterology & hepatology · 2022Article
- Clinical codes combined with procedure codes increase diagnostic accuracy of Crohn's disease in a US Military health record.BMJ open gastroenterology · 2020Article
- Mast Cells Exert Anti-Inflammatory Effects in an IL10Mediators of inflammation · 2018Article
- Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.Annals of internal medicine · 2015Article
- Smoking increases the risk of extraintestinal manifestations in Crohn's disease.World journal of gastroenterology · 2014Article
- Challenges in designing a national surveillance program for inflammatory bowel disease in the United States.Inflammatory bowel diseases · 2014Review
- Serious upper gastrointestinal complications of NSAIDs and COX-2 selective agents.Inflammopharmacology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimIntestinal and extra-intestinal complications are associated with inflammatory bowel disease (IBD) but their exact incidence is not well known. In order to improve our understanding of their incidence and impact, we assessed the complications associated with ulcerative colitis (UC) and Crohn's disease (CD) in a population-based study in Medicaid patients.
methodsWe utilized a retrospective cohort design and identified cases of UC and CD using Medi-Cal, the Medicaid program for the State of California. The disease cohort was age- and gender-matched to four controls each and the intestinal and extra-intestinal complications of CD and UC (analyzed separately) were studied over a period of 5 years following the initial diagnosis.
resultsFor UC, the total number of intestinal complications, per 100 cases, was 92 observed compared to 21 expected; the total number of extra-intestinal complications was 42 observed compared to 30 expected. For CD, the number of intestinal complications was 81 observed compared to 20 expected and for extra-intestinal complications, 37 observed compared to 26 expected (all p < 0.001). For both UC and CD, bleeding was the most frequently seen intestinal complication, while the most common extra-intestinal complication was osteoporosis.
conclusionsIBD is associated with several intestinal and extra-intestinal complications of variable incidence and risk. Success of therapeutic regimens should be measured by decreases in incidence, risks, and costs of these complications, in addition to the usual impact on disease activity.
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