ArticleJournal of gastroenterology2010
The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype.
Article in Journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn's disease.BMC gastroenterology · 2025Article
- SAR Consensus Recommendations for Defining Small Bowel Crohn Disease Strictures at CT and MR Enterography.Radiology · 2025Review
- NOD2 and Crohn's Disease Clinical Practice: From Epidemiology to Diagnosis and Therapy, Rewired.Inflammatory bowel diseases · 2025Review
- Fibroblast-derived interleukin-11 as a potential biomarker for intestinal fibrostenosis in Crohn's disease.Therapeutic advances in gastroenterology · 2025Article
- Crohn's disease related strictures in cross-sectional imaging: More than meets the eye?United European gastroenterology journal · 2022Review
- Interventional inflammatory bowel disease: endoscopic therapy of complications of Crohn's disease.Gastroenterology report · 2022Review
- Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease.Gastroenterology report · 2021Article
- Prevention and Treatment of Stricturing Crohn's Disease - Perspectives and Challenges.Expert review of gastroenterology & hepatology · 2021Review
- Correlation between age of onset and gastrointestinal stenosis in hospitalized patients with Crohn's disease.World journal of clinical cases · 2020Article
- Natural history, diagnosis and treatment approach to fibrostenosing Crohn's disease.United European gastroenterology journal · 2020Review
- Article
- Evaluation of Small-Bowel Patency in Crohn's Disease: Prospective Study with a Patency Capsule and Computed Tomography.GE Portuguese journal of gastroenterology · 2019Article
- The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease.International journal of colorectal disease · 2019Article
- Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases.Gastroenterology · 2017Review
- Novel biomarkers of fibrosis in Crohn's disease.World journal of gastrointestinal pathophysiology · 2016Review
- Genetic Influences on the Development of Fibrosis in Crohn's Disease.Frontiers in medicine · 2016Review
- Genetic studies of Crohn's disease: past, present and future.Best practice & research. Clinical gastroenterology · 2014Review
- Clinical and genetic factors predicting response to therapy in patients with Crohn's disease.United European gastroenterology journal · 2014Article
- Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsWe analyzed the prevalence of concomitant intestinal stenosis in patients with fistulizing Crohn's disease (CD), including the NOD2/CARD15 and IL23R genotype status.
methodsMedical records of n = 1,110 patients with inflammatory bowel diseases were screened for patients with fistulizing and stricturing CD. Study inclusion required diagnosis of stenosis made within 6 months of diagnosing fistulas. CD-associated NOD2 and IL23R variants were genotyped. Similarly, we prospectively investigated 42 patients presenting with fistulizing CD.
resultsIn the retrospective study (n = 333 CD patients), fistulas were found in 145 (43.5%) patients and stenoses in 223 (67.0%) patients. Concomitant stenosis was diagnosed in 125 patients with fistulas resulting in a positive predictive value (PPV) of 86.2% for fistulas predicting intestinal stenosis (p = 5.53 x 10(-11); OR 5.74, 95% CI 3.22-10.50). In logistic regression analysis, presence of fistulas (OR 4.51; 95% CI 2.54-8.01, p = 2.68 x 10(-7)) and disease duration (OR 1.09; 95% CI 1.05-1.13; p = 3.19 x 10(-6)) were strongly associated with intestinal stenosis. NOD2 genotype information, but not IL23R status, increased the PPV for the correct diagnosis of stenosis (PPV = 89.9%). All homozygous carriers (100%) of NOD2 variants with fistulizing CD were diagnosed with stenosis; 1007fs homozygotes were found more often among patients with fistulas and stenoses than in patients without stenoses and fistulas (p = 0.00037). Similar results were found in the prospective analysis, in which 83.3% of the patients with fistulizing CD had concomitant stenosis.
conclusionFistulizing CD is strongly associated with concomitant intestinal stenosis, particularly in homozygous carriers of NOD2 mutations.
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