ArticleInternational journal of physiology, pathophysiology and pharmacology2009
Notch signaling and neurogenesis in normal and stroke brain.
Article in International journal of physiology, pathophysiology and pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Melatonin modulates the Notch1 signaling pathway and Sirt3 in the hippocampus of hypoxic-ischemic neonatal rats.Scientific reports · 2024Article
- Article
- Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?International journal of molecular sciences · 2023Review
- Activation of CREB-binding protein ameliorates spinal cord injury in tabersonine treatment by suppressing NLRP3/Notch signaling.Archives of medical science : AMS · 2023Article
- Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice.Translational stroke research · 2022Article
- Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review.Open biology · 2022Review
- Identification, Culture and Targeting of Cancer Stem Cells.Life (Basel, Switzerland) · 2022Review
- A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.Scientific reports · 2018Article
- Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms.The international journal of neuropsychopharmacology · 2018Article
- Comparative regenerative mechanisms across different mammalian tissues.NPJ Regenerative medicine · 2018Review
- Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders.Neurochemical research · 2017Review
- Folate receptor alpha is more than just a folate transporter.Neurogenesis (Austin, Tex.) · 2017Article
- Notch signaling in cerebrovascular diseases (Review).Molecular medicine reports · 2016Review
- The developmental origins of the mammalian ovarian reserve.Development (Cambridge, England) · 2015Review
- Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage.Frontiers in cellular neuroscience · 2014Review
- Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells.Stem cells and development · 2013Article
- Potentials of endogenous neural stem cells in cortical repair.Frontiers in cellular neuroscience · 2012Article
- Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations.The Lancet. Neurology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Adult neuronal stem cells (NSCs) hold great promise for brain repair because of their unique location within the central nervous system, their potential to proliferate and to differentiate into all major neural lineages, and their ability to functionally incorporate into existing neuronal circuitry after stroke. Nevertheless, the ability to exploit these cells for therapeutic purposes is hampered by the lack of knowledge about the signals that control the generation of a functional neuron from adult NSCs after stroke, particularly in the aged brain. Therefore, to further define the regulatory mechanisms that underlie neurogenesis after stroke, it is critically important to develop future NSC-based repair strategies. Notch signaling defines a fundamental pathway controlling cell fate acquisition. Studies have shown that Notch signaling pathways play critical roles during the maintenance, proliferation, and differentiation of NSCs in the developing brain. Recent evidence shows that Notch1 signaling is conserved in the regulation of adult neurogenesis. Here we summarize current knowledge about the role of Notch signaling in the regulation of neurogenesis in the normal and stroke brain.
Indexed as
Identifiers
20428478PMC2860305W130424401What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.