ArticleExperimental and clinical cardiology2001
Extracellular matrix alterations in cardiomyopathy: The possible crucial role in the dilative form.
Article in Experimental and clinical cardiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A Meta-Analysis Approach to Gene Regulatory Network Inference Identifies Key Regulators of Cardiovascular Diseases.International journal of molecular sciences · 2024Pooled it
- Article
- Whole-Exome Sequencing Revealed New Candidate Genes for Human Dilated Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2022Article
- Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries.Scientific reports · 2022Article
- 3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix.Bioactive materials · 2022Review
- Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac RepairFrontiers in physiology · 2022Article
- A Study of Gene Expression, Structure, and Contractility of iPSC-Derived Cardiac Myocytes from a Family with Heart Disease due to LMNA Mutation.Annals of biomedical engineering · 2021Article
- Microfluidic and Organ-on-a-Chip Approaches to Investigate Cellular and Microenvironmental Contributions to Cardiovascular Function and Pathology.Frontiers in bioengineering and biotechnology · 2021Review
- Multi-Modality Imaging for the Identification of Arrhythmogenic Substrates Prior to Electrophysiology Studies.Frontiers in cardiovascular medicine · 2021Review
- An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy.International journal of molecular sciences · 2020Article
- Losing Regulation of the Extracellular Matrix is Strongly Predictive of Unfavorable Prognostic Outcome after Acute Myocardial Infarction.International journal of molecular sciences · 2020Article
- Disease-inspired tissue engineering: Investigation of cardiovascular pathologies.ACS biomaterials science & engineering · 2020Review
- Network-based computational approach to identify genetic links between cardiomyopathy and its risk factors.IET systems biology · 2020Article
- Multimodality Imaging to Guide Ventricular Tachycardia Ablation in Patients with Non-ischaemic Cardiomyopathy.Arrhythmia & electrophysiology review · 2020Review
- Extracellular Matrix Disparities in anFrontiers in cardiovascular medicine · 2020Article
- Engineering hiPSC cardiomyocyte in vitro model systems for functional and structural assessment.Progress in biophysics and molecular biology · 2019Review
- Dissecting the Role of the Extracellular Matrix in Heart Disease: Lessons from the Drosophila Genetic Model.Veterinary sciences · 2017Review
- New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process.PloS one · 2016Article
- Alcohol Differentially Alters Extracellular Matrix and Adhesion Molecule Expression in Skeletal Muscle and Heart.Alcoholism, clinical and experimental research · 2015Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The collagen network, part of the myocardial extracellular matrix (EM), and other EM proteins transmit mechanical forces generated by cardiomyocytes to cardiac cavities. Network rearrangement and enlargement - fibrosis - is an essential component of cardiac remodelling at various pathological stages. In particular, similarly abundant fibrosis occurs in dilated, hypertrophic and restrictive cardiomyopathy, and it is unclear how this relates to respective changes in ventricular cavities and size. Recent studies of hereditary forms have provided evidence that, in hypertrophic cardiomyopathy, the primary changes occur within cardiomyocytes that are subjected to either necrosis or mutations in genes that code for contractile proteins, while gene mutations of EM proteins have not been found. In contrast, in dilative cardiomyopathy, gene mutations of dystrophin, merosin and other proteins connecting the collagen matrix to cardiomyocyte membranes and actin filaments have been found. A distortion of the mechanical link between the contractile apparatus and the collagen matrix may disturb force transmission in both directions and lead to decreased developed pressure and increased end-systolic volume, provoking cardiac dilation. Profound alterations in the EM have also been induced acutely by alcohol, adriamycin or a high pacing rate, resulting in the development of dilative cardiomyopathy. Thus, EM alterations may be the primary factor in the pathogenesis of dilative cardiomyopathy.
Indexed as
Identifiers
20428444PMC2858965W319644150What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.