ArticleBulletin of the World Health Organization2010
Cardiovascular risk factor trends and potential for reducing coronary heart disease mortality in the United States of America.
Article in Bulletin of the World Health Organization, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis.Journal of human hypertension · 2024Pooled it
- Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.The Cochrane database of systematic reviews · 2015Pooled it
- Trial
- Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial.Journal of human hypertension · 2012Trial
- Efficacy of a brief multifactorial adherence-based intervention on reducing the blood pressure of patients with poor adherence: protocol for a randomized clinical trial.BMC cardiovascular disorders · 2010Trial
- Telemedicine-Supported Intervention Versus Standard Care for Managing Cardiovascular Risk Factors in a Socially Deprived Urban Population: A Prospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Investigating the Impact of the Stationarity Hypothesis on Heart Failure Detection using Deep Convolutional Scattering Networks and Machine Learning.Scientific reports · 2025Article
- The Nutritional Significance ofFood science & nutrition · 2025Review
- Association between COVID-19 vaccination and coronary heart disease: based on 2023 national health interview survey data.Frontiers in public health · 2025Article
- Association of Socioeconomic Status With Life's Essential 8 Varies by Race and Ethnicity.Journal of the American Heart Association · 2023Article
- Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2023Review
- A Systematic Review of Major Cardiovascular Risk Factors: A Growing Global Health Concern.Cureus · 2022Review
- The promise of the gut microbiome as part of individualized treatment strategies.Nature reviews. Gastroenterology & hepatology · 2022Review
- Eicosanoids: Atherosclerosis and cardiometabolic health.Journal of clinical & translational endocrinology · 2020Review
- Trends in Mortality Rates from Cardiovascular Disease and Cancer between 2000 and 2015 in the Most Populous Capital Cities of the Five Regions of Brazil.Arquivos brasileiros de cardiologia · 2020Article
- A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes.Current pharmaceutical design · 2019Review
- Biochemical Activity and Hypoglycemic Effects ofBioMed research international · 2018Article
- Validity of a method for the self-screening of cardiovascular risk.Clinical epidemiology · 2018Article
- Modeling the Burden of Cardiovascular Diseases in Iran from 2005 to 2025: The Impact of Demographic Changes.Iranian journal of public health · 2017Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the potential for reducing cardiovascular risk factors in the United States of America enough to cause age-adjusted coronary heart disease (CHD) mortality rates to drop by 20% (from 2000 baseline figures) by 2010, as targeted under the Healthy People 2010 initiative.
methodsUsing a previously validated, comprehensive CHD mortality model known as IMPACT that integrates trends in all the major cardiovascular risk factors, stratified by age and sex, we calculated how much CHD mortality would drop between 2000 and 2010 in the projected population of the United States aged 25-84 years (198 million). We did this for three assumed scenarios: (i) if recent risk factor trends were to continue to 2010; (ii) success in reaching all the Healthy People 2010 risk factor targets, and (iii) further drops in risk factors, to the levels already seen in the low-risk stratum.
findingsIf age-adjusted CHD mortality rates observed in 2000 remained unchanged, some 388,000 CHD deaths would occur in 2010. First scenario: if recent risk factor trends continued to 2010, there would be approximately 19,000 fewer deaths than in 2000. Although improved total cholesterol, lowered blood pressure in men, decreased smoking and increased physical activity would account for some 51,000 fewer deaths, these would be offset by approximately 32,000 additional deaths from adverse trends in obesity and diabetes and in blood pressure in women. Second scenario: If Healthy People 2010 cardiovascular risk factor targets were reached, approximately 188,000 CHD deaths would be prevented. Scenario three: If the cardiovascular risk levels of the low-risk stratum were reached, approximately 372,000 CHD deaths would be prevented.
conclusionAchievement of the Healthy People 2010 cardiovascular risk factor targets would almost halve the predicted CHD death rates. Additional reductions in major risk factors could prevent or postpone substantially more deaths from CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.