ArticlePloS one2010
Temporal characterization of homology-independent centromere coupling in meiotic prophase.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- Meiosis in budding yeast.Genetics · 2023Article
- The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing.Frontiers in cell and developmental biology · 2023Review
- Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptations for centromere function in meiosis.Essays in biochemistry · 2020Review
- DNA Helicase Mph1Developmental cell · 2020Article
- Review
- Slx5p-Slx8p Promotes Accurate Chromosome Segregation by Mediating the Degradation of Synaptonemal Complex Components during Meiosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Evidence ofG3 (Bethesda, Md.) · 2018Article
- A ZIP1 separation-of-function allele reveals that centromere pairing drives meiotic segregation of achiasmate chromosomes in budding yeast.PLoS genetics · 2018Review
- Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae.Genetics · 2017Article
- Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.Science (New York, N.Y.) · 2017Article
- Article
- Centromere pairing--tethering partner chromosomes in meiosis I.The FEBS journal · 2015Review
- Article
- The meiotic checkpoint network: step-by-step through meiotic prophase.Cold Spring Harbor perspectives in biology · 2014Review
- Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosis.Chromosoma · 2014Review
- Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dual mechanisms prevent premature chromosome segregation during meiosis.Genes & development · 2013Article
- Quantitative high resolution mapping of HvMLH3 foci in barley pachytene nuclei reveals a strong distal bias and weak interference.Journal of experimental botany · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOver the past thirty years several reports of the pairing or association of non-homologous centromeres during meiotic prophase have appeared in the literature. Recently, the homology-independent pairwise association of centromeres, termed centromere coupling, was also reported in budding yeast. It seems paradoxical that centromeres would pair with non-homologous partners during a process intended to align homologous chromosomes, yet the conservation of this phenomenon across a wide range of species suggests it may play an important role in meiosis. PRINCIPAL
findingsTo better define the role of this phenomenon in budding yeast, experiments were preformed to place centromere coupling within the context of landmark meiotic events. Soon after the initiation of the meiotic program, centromeres were found to re-organize from a single cluster into non-homologous couples. Centromere coupling is detected as soon as chromosome replication is finished and persists while the recombination protein Dmc1 is loaded onto the chromosomes, suggesting that centromere coupling persists through the time of double strand break formation. In the absence of the synaptonemal complex component, Zip1, centromere coupling was undetectable, at all times examined, confirming the essential role of this protein on this process. Finally, the timely release of centromere coupling depends on the recombination-initiating enzyme, Spo11, suggesting a connection between events in homologous pairing/recombination and the regulation of centromere coupling.
conclusionsBased on our results we propose a role for centromere coupling in blocking interactions between homologous centromeres as recombination initiation is taking place.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.