ArticleThe American journal of clinical nutrition2010
Plasma phytanic acid concentration and risk of prostate cancer: results from the European Prospective Investigation into Cancer and Nutrition.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians.The Journal of nutrition · 2013Trial
- Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study.Lipids in health and disease · 2011Trial
- Phytanic acid, an inconclusive phytol metabolite: A review.Current research in toxicology · 2023Article
- Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review.The British journal of nutrition · 2022Review
- Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2020Review
- Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition.International journal of cancer · 2020Article
- Dietary influences on tissue concentrations of phytanic acid and AMACR expression in the benign human prostate.The Prostate · 2015Article
- Serum phytanic and pristanic acid levels and prostate cancer risk in Finnish smokers.Cancer medicine · 2014Article
- Article
- Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition.International journal of cancer · 2013Article
- Phytanic acid and the risk of non-Hodgkin lymphoma.Carcinogenesis · 2013Article
- Estimated phytanic acid intake and prostate cancer risk: a prospective cohort study.International journal of cancer · 2012Article
- AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk.The Prostate · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 16 institutions in 7 countries.
Funding
Abstract
backgroundPhytanic acid, a fatty acid predominantly obtained from foods high in ruminant fat, may have a biological role in the up-regulation of the protein alpha-methylacyl-coenzyme A racemase, which is overexpressed in prostate cancer tissue.
objectiveThis study aimed to examine the association between plasma concentrations of phytanic acid and subsequent risk of prostate cancer.
designWithin the European Prospective Investigation into Cancer and Nutrition cohort, 566 incident prostate cancer cases from Germany, Greece, Italy, the Netherlands, Spain, and the United Kingdom were individually matched to 566 controls by study center, age at recruitment, and time of day and duration of fasting at blood collection. Phytanic acid concentrations were measured by using a gas chromatography-mass spectrometry assay.
resultsIn controls, plasma phytanic acid concentration was strongly correlated with dairy fat intake (r = 0.49, P < 0.0001), varied significantly by country (P for heterogeneity < 0.0001), and decreased with age (P for trend = 0.02) and duration of fasting at blood collection (P for trend = 0.002). There was no significant association of phytanic acid with prostate cancer risk overall (odds ratio for a doubling in concentration: 1.05; 95% CI: 0.91, 1.21; P for trend = 0.53) or by stage or grade of disease. However, in men who had fasted (>3 h) at blood collection, the odds ratio for prostate cancer was 1.27 (95% CI: 1.01, 1.60; P for trend = 0.04).
conclusionPlasma phytanic acid concentration is significantly associated with intake of dairy fat but not with overall risk of prostate cancer in this European population.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.