ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Maternal Overweight Downregulates MME (Neprilysin) in Feto-Placental Endothelial Cells and in Cord Blood.International journal of molecular sciences · 2020Trial
- The Molecular Link between Obesity and the Endometrial Environment: A Starting Point for Female Infertility.International journal of molecular sciences · 2024Review
- Placental adaptations supporting fetal growth during normal and adverse gestational environments.Experimental physiology · 2023Review
- W3112: Reproductive Performance in Domestic Ruminants.Journal of animal science · 2022Article
- A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition.International journal of environmental research and public health · 2020Article
- Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis.Nutrients · 2020Article
- Oxidative Stress and Inflammation in Sows with Excess Backfat: Up-Regulated Cytokine Expression and Elevated Oxidative Stress Biomarkers in Placenta.Animals : an open access journal from MDPI · 2019Article
- Risk of hypertension following perinatal adversity: IUGR and prematurity.The Journal of endocrinology · 2019Review
- Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus.BMC genomics · 2018Article
- Effects of maternal western-style diet on amniotic fluid volume and amnion VEGF profiles in a nonhuman primate model.Physiological reports · 2018Article
- Excessive backfat of sows at 109 d of gestation induces lipotoxic placental environment and is associated with declining reproductive performance.Journal of animal science · 2018Article
- Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.The Journal of physiology · 2017Review
- Article
- Placental Origins of Chronic Disease.Physiological reviews · 2016Review
- Impact of maternal obesity on fetal programming of cardiovascular disease.Physiology (Bethesda, Md.) · 2015Review
- Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.Physiological reports · 2015Article
- Angiogenesis in the placenta: the role of reactive oxygen species signaling.BioMed research international · 2015Review
- Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.American journal of physiology. Endocrinology and metabolism · 2013Article
- Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring.Reproductive biology and endocrinology : RB&E · 2013Article
- Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In pregnant sheep, maternal:fetal exchange occurs across placentomes composed of placental cotyledonary and uterine caruncular tissues. Recently, we reported that fetal weights of obese (OB) ewes [fed a diet of 150% of National Research Council (NRC) recommendations] were approximately 30% greater than those of control (C) ewes (fed a diet 100% of NRC recommendations) at midgestation (MG), but fetal weights were similar in late gestation (LG). Transplacental nutrient exchange is dependent on placental blood flow, which itself is dependent on placental vascularity. The current study investigated whether the observed initial faster and subsequent slower fetal growth rate of OB compared with C was associated with changes in cotyledonary vascularity and expression of angiogenic factors (vascular endothelial growth factor, fibroblast growth factor-2, placental growth factor, angiopoietin-1 and -2). Cotyledonary arteriole diameters were markedly greater (P < 0.05) in OB than C ewes at MG, but while arteriole diameter of C ewes increased (P < 0.05) from MG to LG, they remained unchanged in OB ewes. Cotyledonary arterial angiogenic factors mRNA and protein expression were lower (P < 0.05) in OB than C ewes at MG and remained low from MG to LG. In contrast, mRNA levels of angiogenic factors in C ewes declined from high levels at MG to reach those of OB ewes by LG. The increase in cotyledonary arteriole diameter in early to MG may function to accelerate fetal growth rate in OB ewes, while the decreased cotyledonary arterial angiogenic factors from MG-LG may function to protect the fetus from excessive placental vascular development, increased maternal nutrient delivery, and excessive weight gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.