Diabetes, insulin use, and cancer risk: are observational studies part of the solution-or part of the problem?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

29 citing papers in PubMed, 9 syntheses or guidelines pooled it.

1. Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis.European journal of nutrition · 2019
   Pooled it
2. Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis.International journal of environmental research and public health · 2019
   Pooled it
3. Metformin use improves survival of diabetic liver cancer patients: systematic review and meta-analysis.Oncotarget · 2016 · on this map
   Pooled it
4. Effects of metformin on survival outcomes of lung cancer patients with type 2 diabetes mellitus: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016
   Pooled it
5. Effect of Diabetes Mellitus on Survival in Patients with Pancreatic Cancer: A Systematic Review and Meta-analysis.Scientific reports · 2015
   Pooled it
6. Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis.The oncologist · 2015 · on this map
   Pooled it
7. Association between irrigation fluids, washout volumes and risk of local recurrence of anterior resection for rectal cancer: a meta-analysis of 427 cases and 492 controls.PloS one · 2014
   Pooled it
8. Low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observational studies.PloS one · 2013
   Pooled it
9. Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.PloS one · 2012
   Pooled it
10. The effect of metformin on apoptosis in a breast cancer presurgical trial.British journal of cancer · 2013
    Trial
11. Insulin resistance and cancer: molecular links and clinical perspectives.Molecular and cellular biochemistry · 2025
    Review
12. Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond.Frontiers in endocrinology · 2022
    Article
13. Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs.Cells · 2019
    Review
14. Activation of cancer-related and mitogen-activated protein kinase signaling pathways in human mature osteoblasts isolated from patients with type 2 diabetes.Bone reports · 2019
    Article
15. Anti-Diabetic Drugs: Cure or Risk Factors for Cancer?Pathology oncology research : POR · 2018
    Review
16. Favourable changes in mortality in people with diabetes: US NHANES 1999-2010.Diabetes, obesity & metabolism · 2018
    Article
17. Decreased Levels of Circulating Cancer-Associated Protein Biomarkers Following Bariatric Surgery.Obesity surgery · 2017
    Article
18. The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.Science signaling · 2015
    Article
19. Validation of methods to control for immortal time bias in a pharmacoepidemiologic analysis of renin-angiotensin system inhibitors in type 2 diabetes.Journal of epidemiology · 2014
    Article
20. Insulin therapy and cancer.Diabetes care · 2013
    Review

Corrections and comments

• Comment on
  Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry.2010

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as