Evidence map›Paper›PMID 20427683›Full record

Trial reportDiabetes care2010

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.

Magnus Löndahl, Per Katzman, Anders Nilsson, Christer Hammarlund

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02221466 (Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.), which is not on this map. Cited by 137 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 11 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02221466 completednot on this mapstarted 2014, after this paper: background citation

Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.

TypeobservationalSponsorOle HyldegaardRan2014 to 2016Enrolled45ConditionsDiabetic Peripheral Vascular Disease
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 11 syntheses or guidelines pooled it, 431 citations in OpenAlex.

  1. Pooled it
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  5. Guideline
  6. Pooled it
  7. Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020
    Pooled it
  8. Guideline
  9. Hyperbaric oxygen therapy for chronic wounds.The Cochrane database of systematic reviews · 2015
    Pooled it
  10. Diabetes: foot ulcers and amputations.BMJ clinical evidence · 2011
    Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Review
  17. Review
  18. Observational
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  20. Review

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Magnus LöndahlInstitution for Clinical Sciences in Lund, Lund University, Lund, Sweden. magnus.londahl@med.lu.se
Per Katzman
Anders Nilsson
Christer Hammarlund
Lund University · SEHelsingborgs lasarett · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers. RESEARCH DESIGN AND

methodsThe Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study was a randomized, single-center, double-blinded, placebo-controlled clinical trial. The outcomes for the group receiving HBOT were compared with those of the group receiving treatment with hyperbaric air. Treatments were given in a multi-place hyperbaric chamber for 85-min daily (session duration 95 min), five days a week for eight weeks (40 treatment sessions). The study was performed in an ambulatory setting.

resultsNinety-four patients with Wagner grade 2, 3, or 4 ulcers, which had been present for >3 months, were studied. In the intention-to-treat analysis, complete healing of the index ulcer was achieved in 37 patients at 1-year of follow-up: 25/48 (52%) in the HBOT group and 12/42 (29%) in the placebo group (P = 0.03). In a sub-analysis of those patients completing >35 HBOT sessions, healing of the index ulcer occurred in 23/38 (61%) in the HBOT group and 10/37 (27%) in the placebo group (P = 0.009). The frequency of adverse events was low.

conclusionsThe HODFU study showed that adjunctive treatment with HBOT facilitates healing of chronic foot ulcers in selected patients with diabetes.

Indexed as

Wound HealingAdultAgedAged, 80 and overAirAmputation, SurgicalChronic DiseaseDiabetic FootFemaleFollow-Up StudiesHumansHyperbaric OxygenationMaleMiddle AgedPlacebosTreatment OutcomePlacebos

Identifiers

PMID20427683
PMCPMC2858204
OpenAlexW2143723758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.