ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Burst-induced anti-Hebbian depression acts through short-term synaptic dynamics to cancel redundant sensory signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Anti-Hebbian plasticity in the motor cortex promotes defensive freezing.Current biology : CB · 2023Article
- Article
- Internally Generated Predictions Enhance Neural and Behavioral Detection of Sensory Stimuli in an Electric Fish.Neuron · 2018Article
- Burst Firing in the Electrosensory System of Gymnotiform Weakly Electric Fish: Mechanisms and Functional Roles.Frontiers in computational neuroscience · 2016Review
- Balanced ionotropic receptor dynamics support signal estimation via voltage-dependent membrane noise.Journal of neurophysiology · 2016Article
- Activation of parallel fiber feedback by spatially diffuse stimuli reduces signal and noise correlations via independent mechanisms in a cerebellum-like structure.PLoS computational biology · 2015Article
- Transcutaneous induction of stimulus-timing-dependent plasticity in dorsal cochlear nucleus.Frontiers in systems neuroscience · 2015Article
- A role for mixed corollary discharge and proprioceptive signals in predicting the sensory consequences of movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Subtractive, divisive and non-monotonic gain control in feedforward nets linearized by noise and delays.Frontiers in computational neuroscience · 2014Article
- Excitatory and inhibitory STDP jointly tune feedforward neural circuits to selectively propagate correlated spiking activity.Frontiers in computational neuroscience · 2014Article
- Reversed timing-dependent associative plasticity in the human brain through interhemispheric interactions.Journal of neurophysiology · 2013Article
- Learning contrast-invariant cancellation of redundant signals in neural systems.PLoS computational biology · 2013Article
- The spike-timing dependence of plasticity.Neuron · 2012Review
- Bursts and isolated spikes code for opposite movement directions in midbrain electrosensory neurons.PloS one · 2012Article
- Bursting neurons and ultrasound avoidance in crickets.Frontiers in neuroscience · 2012Article
- Glutamatergic inputs and glutamate-releasing immature inhibitory inputs activate a shared postsynaptic receptor population in lateral superior olive.Neuroscience · 2011Article
- Coding movement direction by burst firing in electrosensory neurons.Journal of neurophysiology · 2011Article
- Mechanisms underlying input-specific expression of endocannabinoid-mediated synaptic plasticity in the dorsal cochlear nucleus.Hearing research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Weakly electric fish can enhance the detection and localization of important signals such as those of prey in part by cancellation of redundant spatially diffuse electric signals due to, e.g., their tail bending. The cancellation mechanism is based on descending input, conveyed by parallel fibers emanating from cerebellar granule cells, that produces a negative image of the global low-frequency signals in pyramidal cells within the first-order electrosensory region, the electrosensory lateral line lobe (ELL). Here we demonstrate that the parallel fiber synaptic input to ELL pyramidal cell undergoes long-term depression (LTD) whenever both parallel fiber afferents and their target cells are stimulated to produce paired burst discharges. Paired large bursts (4-4) induce robust LTD over pre-post delays of up to +/-50 ms, whereas smaller bursts (2-2) induce weaker LTD. Single spikes (either presynaptic or postsynaptic) paired with bursts did not induce LTD. Tetanic presynaptic stimulation was also ineffective in inducing LTD. Thus, we have demonstrated a form of anti-Hebbian LTD that depends on the temporal correlation of burst discharge. We then demonstrated that the burst-induced LTD is postsynaptic and requires the NR2B subunit of the NMDA receptor, elevation of postsynaptic Ca(2+), and activation of CaMKIIbeta. A model incorporating local inhibitory circuitry and previously identified short-term presynaptic potentiation of the parallel fiber synapses further suggests that the combination of burst-induced LTD, presynaptic potentiation, and local inhibition may be sufficient to explain the generation of the negative image and cancellation of redundant sensory input by ELL pyramidal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.