ArticleMolecular biology of the cell2010
Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Role of Caveolae family-related proteins in the development of breast cancer.Frontiers in molecular biosciences · 2023Review
- PV1 in Caveolae Controls Lung Endothelial Permeability.American journal of respiratory cell and molecular biology · 2020Article
- Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells.Oxidative medicine and cellular longevity · 2020Article
- Article
- Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop.Oncotarget · 2017Article
- Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology.American journal of physiology. Cell physiology · 2017Review
- High cell-surface density of HER2 deforms cell membranes.Nature communications · 2016Article
- Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis.Traffic (Copenhagen, Denmark) · 2015Article
- Cavin family proteins and the assembly of caveolae.Journal of cell science · 2015Review
- Tagging strategies strongly affect the fate of overexpressed caveolin-1.Traffic (Copenhagen, Denmark) · 2015Article
- mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer.PloS one · 2015Article
- Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation.Diabetes · 2014Article
- EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development.Developmental biology · 2014Article
- Overexpression of caveolin-1 is sufficient to phenocopy the behavior of a disease-associated mutant.Traffic (Copenhagen, Denmark) · 2013Article
- Identification of caveolin-1 as a potential causative factor in the generation of trastuzumab resistance in breast cancer cells.Journal of Cancer · 2013Article
- Seg1 controls eisosome assembly and shape.The Journal of cell biology · 2012Article
- Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content.Molecular biology of the cell · 2012Article
- Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1.PloS one · 2012Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Caveolin-1 and caveolae are often lost in cancer. We found that levels of caveolin-1 and polymerase I and transcript release factor (PTRF)/cavin-1 correlated closely in a panel of cancer and normal cells. Caveolin-1 reexpression in cancer cells lacking both proteins induced formation of long membrane tubules rarely seen in normal cells. PTRF/cavin-1 inhibited tubule formation when coexpressed with caveolin-1 in these cells, whereas suppression of PTRF/cavin-1 expression in cells that normally expressed both genes stimulated tubule formation by endogenous caveolin-1. Caveolin-1 tubules shared several features with previously described Rab8 tubules. Coexpressed Rab8 and caveolin-1 labeled the same tubules (as did EHD proteins), and synergized to promote tubule formation, whereas a dominant-interfering Rab8 mutant inhibited caveolin-1 tubule formation. Both overexpression and inhibition of dynamin-2 reduced the abundance of caveolin-1 tubules. Caveolin-1 reexpression in SK-BR-3 breast cancer cells also induced formation of short membrane tubules close to cortical actin filaments, which required actin filaments but not microtubules. Actomyosin-induced tension destabilized both long and short tubules; they often snapped and resolved to small vesicles. Actin filament depolymerization or myosin II inhibition reduced tension and stabilized tubules. These data demonstrate a new function for PTRF/cavin-1, a new functional interaction between caveolin-1 and Rab8 and that actomyosin interactions can induce tension on caveolin-1-containing membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.