ArticleDisease models & mechanisms
Insights into the role of DNA methylation in disease through the use of mouse models.
Article in Disease models & mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing.Communications biology · 2024Article
- DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease.Kidney international · 2024Article
- Vpr driving DNA methylation variation of CD4 + T cells in HIV-1 infection.Virology journal · 2024Article
- Generating Sequencing-Based DNA Methylation Maps from Low DNA Input Samples.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Gene Body Methylation of the Lymphocyte-Specific GeneMolecular cancer research : MCR · 2021Article
- Obesity, metabolic health and omics: Current status and future directions.World journal of diabetes · 2021Review
- Cigarette smoke-induced alterations in blood: A review of research on DNA methylation and gene expression.Experimental and clinical psychopharmacology · 2021Review
- Article
- Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021Review
- Effects of Prenatal Exposure to Titanium Dioxide Nanoparticles on DNA Methylation and Gene Expression Profile in the Mouse Brain.Frontiers in toxicology · 2021Article
- DNA methylome signatures as epigenetic biomarkers of hexanal associated with lung toxicity.PeerJ · 2021Article
- Article
- Integrative (epi) Genomic Analysis to Predict Response to Androgen-Deprivation Therapy in Prostate Cancer.EBioMedicine · 2018Article
- Comparative Methylome Analysis Reveals Perturbation of Host Epigenome in Chestnut Blight Fungus by a Hypovirus.Frontiers in microbiology · 2018Article
- DDMGD: the database of text-mined associations between genes methylated in diseases from different species.Nucleic acids research · 2015Article
- Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma.Medicina oral, patologia oral y cirugia bucal · 2014Article
- Genome-wide analysis of DNA methylation patterns in horse.BMC genomics · 2014Article
- Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.Seminars in neurology · 2014Review
- DNA methylome in spleen of avian pathogenic Escherichia coli-challenged broilers and integration with mRNA expression.Scientific reports · 2014Article
- Sex-dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Epigenetics was originally defined as the interaction of genes with their environment that brings the phenotype into being. It now refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. To date, the best understood epigenetic mechanisms are CpG DNA methylation and histone modifications. DNA methylation in particular has been the subject of intense interest because of its recently recognized role in disease, as well as in the development and normal function of organisms. Much of the focus of disease-related research has been on cancer because of the recognition that epigenetic alterations are common in cancer and probably cooperate with genetic alterations to drive cancer formation. Our understanding of epigenetic mechanisms in controlling gene expression has resulted from the study of cell line systems and simple model systems, such as Arabidopsis thaliana. We are now moving into an era of more complex model systems, such as transgenic and knockout mouse models, which will lead to further insight into epigenetics in development and human disease. The current models have revealed complex, tissue-specific effects of epigenetic mechanisms and have further informed our understanding of the role of DNA methylation and histone modifications on disease and development. The current state of these models is the subject of this Commentary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.