ArticleJournal of virology2010
beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Implication of TIGITNature communications · 2021Article
- Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy.Frontiers in immunology · 2020Article
- Oral cholera vaccination promotes homing of IgAMucosal immunology · 2018Article
- Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.Frontiers in pharmacology · 2015Review
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- Activation of circulated immune cells and inflammatory immune adherence are involved in the whole process of acute venous thrombosis.International journal of clinical and experimental medicine · 2014Article
- Glycoprotein H and α4β1 integrins determine the entry pathway of alphaherpesviruses.Journal of virology · 2013Article
- Roles of cell signaling pathways in cell-to-cell contact-mediated Epstein-Barr virus transmission.Journal of virology · 2012Article
- Integrin β1 mediates vaccinia virus entry through activation of PI3K/Akt signaling.Journal of virology · 2012Article
- Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.PLoS pathogens · 2012Article
- Polymorphisms in the α4 integrin of neotropical primates: insights for binding of natural ligands and HIV-1 gp120 to the human α4β7.PloS one · 2011Article
- The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry.Journal of virology · 2010Article
- Donors define whether CD19(+)CD27(+) tonsillar B cells are mostly memory or germinal-center B cells.Immunology and cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Epstein-Barr virus (EBV) uses nasal mucosa-associated lymphoid tissue (NALT) as a portal of entry to establish life-long persistence in memory B cells. We previously showed that naïve and memory B cells from NALT are equally susceptible to EBV infection. Here we show that memory B cells from NALT are significantly more susceptible to EBV infection than those from remote lymphatic organs. We identify beta(1) integrin, which is expressed the most by naïve B cells of distinct lymphoid origin and by memory B cells from NALT, as a mediator of increased susceptibility to infection by EBV. Furthermore, we show that BMRF-2-beta(1) integrin interaction and the downstream signal transduction pathway are critical for postbinding events. An increase of beta(1) integrin expression in peripheral blood memory B cells provoked by CD40 stimulation plus B-cell receptor cross-linking increased the susceptibility of non-NALT memory B cells to EBV infection. Thus, EBV seems to utilize the increased activation status of memory B cells residing in the NALT to establish and ensure persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.