ArticleAmerican journal of epidemiology2010
Effect of trajectories of glycemic control on mortality in type 2 diabetes: a semiparametric joint modeling approach.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Longitudinal trends in HbADiabetes/metabolism research and reviews · 2018Pooled it
- Laughter yoga as an enjoyable therapeutic approach for glycemic control in individuals with type 2 diabetes: A randomized controlled trial.Frontiers in endocrinology · 2023Trial
- Glycemic Control and Prostate Cancer Mortality Risk in Veterans with Type 2 Diabetes Mellitus.Cancer research communications · 2025Article
- Health Literacy and Behaviors of Patients and Caregivers Related to Glycemic Control Among Individuals With Type 2 Diabetes in Chiang Mai Province, Thailand.Patient preference and adherence · 2025Article
- Time to first optimal glycemic control and its predictors among adult type 2 diabetes patients in Amhara Regional State comprehensive specialized hospitals, Northwest Ethiopia.BMC endocrine disorders · 2024Article
- Risk factors associated with glycated hemoglobin A1c trajectories progressing to type 2 diabetes.Annals of medicine · 2023Article
- Health literacy, self-efficacy, self-care behaviors, and glycemic control among older adults with type 2 diabetes mellitus: a cross-sectional study in Thai communities.BMC geriatrics · 2023Article
- Personalized lab test models to quantify disease potentials in healthy individuals.Nature medicine · 2021Article
- Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24 months follow-up.Journal of gastroenterology · 2020Article
- The Association of Health Literacy Level with Self-Care Behaviors and Glycemic Control in a Low Education Population with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Iran.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Article
- Patient healthcare trajectory. An essential monitoring tool: a systematic review.Health information science and systems · 2017Review
- Quantifying the Race Stratified Impact of Socioeconomics on Graft Outcomes in Kidney Transplant Recipients.Transplantation · 2016Article
- High-risk glycated hemoglobin trajectories established by mid-20s: findings from a birth cohort study.BMJ open diabetes research & care · 2016Article
- Trajectories in glycemic control over time are associated with cognitive performance in elderly subjects with type 2 diabetes.PloS one · 2014Article
- Associations between health literacy, diabetes knowledge, self-care behaviors, and glycemic control in a low income population with type 2 diabetes.Diabetes technology & therapeutics · 2011Article
- Hormonal status in protracted critical illness and in-hospital mortality.Critical care (London, England) · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Data on the effect of trajectories in long-term glycemia and all-cause mortality are lacking. The authors studied the effect of trajectories in long-term glycemic control on all-cause mortality in patients with type 2 diabetes. A cohort of 8,812 veterans with type 2 diabetes was assembled retrospectively using Veterans Affairs registry data. For each veteran in the cohort, a 3-month person-period data set was created from April 1997 to May 2006. The average duration of follow-up was 4.5 years. The overall mortality rate was 15.3%. Using a novel approach for joint modeling of time to death and longitudinal measurements of hemoglobin A1c (HbA1c) level, after adjustment for all significant baseline covariates, baseline HbA1c was found to be significantly associated with mortality (hazard ratio = 2.1, 95% confidence interval: 1.3, 3.6) (i.e., a 1% increase in baseline HbA1c level was associated with an average 2-fold increase in mortality risk). Similarly, the slope of the HbA1c trajectory was marginally significantly associated with mortality (hazard ratio = 7.3, 95% confidence interval: 0.9, 57.1) after adjustment for baseline covariates (i.e., a 1% increase in HbA1c level over 3 months was associated with a 22% increase in mortality risk). The authors conclude that a positive trajectory of long-term hyperglycemia is associated with increased mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.