ArticleJournal of cell science2010
Cell speed, persistence and information transmission during signal relay and collective migration.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 100 citations in OpenAlex.
- A Mathematical Model for Chemo-Mechanically Induced Collective Cell Motility on Planar Elastic Substrates.International journal for numerical methods in biomedical engineering · 2026Article
- Substrate Rigidity Modulates Segmentation Clock Dynamics in Isolated Presomitic Mesoderm Cells.bioRxiv : the preprint server for biology · 2024Article
- Article
- Programmable self-organization of heterogeneous microrobot collectives.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Active wetting of epithelial tissues: modeling considerations.European biophysics journal : EBJ · 2023Review
- Microrobot collectives with reconfigurable morphologies, behaviors, and functions.Nature communications · 2022Article
- Mechanical waves caused by collective cell migration: generation.European biophysics journal : EBJ · 2022Review
- Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction.Frontiers in cell and developmental biology · 2022Article
- A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes.Biomechanics and modeling in mechanobiology · 2021Article
- Exosomes mediate LTB4 release during neutrophil chemotaxis.PLoS biology · 2021Article
- Effects of spatial confinement on migratory properties of Dictyostelium discoideum cells.Communicative & integrative biology · 2021Article
- Multiscale nature of cell rearrangement caused by collective cell migration.European biophysics journal : EBJ · 2021Review
- Morphological and Motility Features of the Stable Bleb-Driven Monopodial Form ofInfection and immunity · 2020Article
- Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Functional Epithelium Remodeling in Response to Applied Stress underApplied bionics and biomechanics · 2019Article
- Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxingJournal of cell science · 2018Article
- Cellular automaton models for time-correlated random walks: derivation and analysis.Scientific reports · 2017Article
- Adenylyl cyclase mRNA localizes to the posterior of polarized DICTYOSTELIUM cells during chemotaxis.BMC cell biology · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Collective migration is a key feature of the social amoebae Dictyostelium discoideum, where the binding of chemoattractants leads to the production and secretion of additional chemoattractant and the relay of the signal to neighboring cells. This then guides cells to migrate collectively in a head-to-tail fashion. We used mutants that were defective in signal relay to elucidate which quantitative metrics of cell migration are most strongly affected by signal relay and collective motion. We show that neither signal relay nor collective motion markedly impact the speed of cell migration. Cells maintained a preferred overall direction of motion for several minutes with similar persistence, regardless of whether or not they were attracted to moving neighbors, moving collectively in contact with their neighbors, or simply following a fixed exogenous signal. We quantitatively establish that signal relay not only increases the number of cells that respond to a chemotactic signal, but most remarkably, also transmits information about the location of the source accurately over large distances, independently of the strength of the exogenous signal. We envision that signal relay has a similar key role in the migration of a variety of chemotaxing mammalian cells that can relay chemoattractant signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.