ArticleThe Journal of biological chemistry2010
Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Murine Models of Familial Cytokine Storm Syndromes.Advances in experimental medicine and biology · 2024Review
- XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.PLoS pathogens · 2023Article
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1.Cell death & disease · 2022Article
- XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.EMBO reports · 2022Article
- Infection-induced inflammation from specific inborn errors of immunity to COVID-19.The FEBS journal · 2021Review
- X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.Cell & bioscience · 2019Article
- ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.Nature communications · 2018Article
- IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.Nature communications · 2018Article
- Recent advances in understanding inhibitor of apoptosis proteins.F1000Research · 2018Review
- Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.The Journal of biological chemistry · 2017Article
- Article
- Impact of inhibitor of apoptosis proteins on immune modulation and inflammation.Immunology and cell biology · 2017Review
- Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.Immunology and cell biology · 2017Review
- Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses.Frontiers in immunology · 2017Article
- A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy.Drug discovery today · 2016Review
- Regulation of Cell Death by IAPs and Their Antagonists.Current topics in developmental biology · 2015Review
- BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.The EMBO journal · 2014Article
- A near death experience: Shigella manipulates host death machinery to silence innate immunity.The EMBO journal · 2014Article
- Ubiquitin in the immune system.EMBO reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obligate intracellular Chlamydophila pneumoniae induce apoptosis resistance in host cells to escape eradication by immune effector cells. Apoptosis resistance depends on the increased expression and stabilization of cellular inhibitor of apoptosis proteins (cIAPs) and X-linked inhibitor of apoptosis protein (XIAP). Here we investigated the role of XIAP in experimental pulmonary infection of mice with C. pneumoniae. XIAP knock out (KO) mice were sensitized for C. pneumoniae infection compared with wild type mice. XIAP was involved in lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and endotoxin shock. Hyper-secretion of tumor necrosis factor-alpha and lower NO in LPS-treated KO mouse macrophages revealed its regulatory role in inflammatory responses. Unexpectedly, activating stimuli like LPS, tumor necrosis factor-alpha, or interferon-gamma very efficiently induced apoptotic cell death in KO macrophages but not in wild type macrophages. Cell survival transcription factor nuclear factor kappaB (NF-kappaB) p65 levels were reduced in lungs and pulmonary macrophages of infected KO mice. Furthermore, a reduced CD8 T cell population and their increased sensitivity for concanavalin A and chlamydial HSP60 stimulation revealed a defect in CD8 T cells in XIAP KO mice. These data demonstrated a role of XIAP for the integrity of both innate and cellular immune responses during C. pneumoniae infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.