ArticleComputational biology and chemistry2010
Potential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design.
Article in Computational biology and chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- FPocketWeb: protein pocket hunting in a web browser.Journal of cheminformatics · 2022Article
- All-atom virus simulations.Current opinion in virology · 2018Review
- Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface.Scientific reports · 2016Article
- New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions.Antiviral research · 2013Review
- AutoGrow 3.0: an improved algorithm for chemically tractable, semi-automated protein inhibitor design.Journal of molecular graphics & modelling · 2013Article
- Recent progress in structure-based anti-influenza drug design.Drug discovery today · 2012Review
- Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction.PloS one · 2012Article
- Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition.PLoS pathogens · 2011Article
- Molecular recognition in the case of flexible targets.Current pharmaceutical design · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pandemic (H1N1) influenza poses an imminent threat. Nations have stockpiled inhibitors of the influenza protein neuraminidase in hopes of protecting their citizens, but drug-resistant strains have already emerged, and novel therapeutics are urgently needed. In the current work, the computer program AutoGrow is used to generate novel predicted neuraminidase inhibitors. Given the great flexibility of the neuraminidase active site, protein dynamics are also incorporated into the computer-aided drug-design process. Several potential inhibitors are identified that are predicted to bind to neuraminidase better than currently approved drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.