ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2010
Neural control of locomotion and training-induced plasticity after spinal and cerebral lesions.
Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Activity-Dependent Transspinal Stimulation for Recovery of Walking Ability After Spinal Cord Injury
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
51 citing papers in PubMed, 107 citations in OpenAlex.
- Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury.Experimental brain research · 2022Trial
- Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury.Brain : a journal of neurology · 2020Trial
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury.PloS one · 2019Trial
- Corticospinal reorganization after locomotor training in a person with motor incomplete paraplegia.BioMed research international · 2013Trial
- Brain stimulation paired with novel locomotor training with robotic gait orthosis in chronic stroke: a feasibility study.NeuroRehabilitation · 2013Trial
- Kunming Locomotor Training: neurological, functional, and autonomic outcomes in complete spinal cord injury.Current opinion in neurology · 2025Review
- An MRI-Compatible System for Characterizing Supraspinal Processing of Walking-Related Foot-Sole Somatosensory Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025Article
- Postsynaptic potentials of soleus motor neurons produced by transspinal stimulation: a human single-motor unit study.Journal of neurophysiology · 2024Article
- Tapping into the human spinal locomotor centres with transspinal stimulation.Scientific reports · 2024Article
- Tapping Into the Human Spinal Locomotor Centres With Transspinal Stimulation.Research square · 2024Article
- Brain Activation Evoked by Motor Imagery in Pediatric Patients with Complete Spinal Cord Injury.AJNR. American journal of neuroradiology · 2023Article
- Article
- Approach to Small Animal Neurorehabilitation by Locomotor Training: An Update.Animals : an open access journal from MDPI · 2022Review
- Physiological effects of cathodal electrode configuration for transspinal stimulation in humans.Journal of neurophysiology · 2022Article
- Investigation of neural and biomechanical impairments leading to pathological toe and heel gaits using neuromusculoskeletal modelling.The Journal of physiology · 2022Article
- Brain and spinal cord paired stimulation coupled with locomotor training facilitates motor output in human spinal cord injury.Frontiers in neurology · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Invasive and Non-Invasive Approaches of Electrical Stimulation to Improve Physical Functioning after Spinal Cord Injury.Journal of clinical medicine · 2021Review
- A Controlled Clinical Study of Intensive Neurorehabilitation in Post-Surgical Dogs with Severe Acute Intervertebral Disc Extrusion.Animals : an open access journal from MDPI · 2021Article
- Transcutaneous Electrical Neuromodulation of the Cervical Spinal Cord Depends Both on the Stimulation Intensity and the Degree of Voluntary Activity for Training. A Pilot Study.Journal of clinical medicine · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standing and walking require a plethora of sensorimotor interactions that occur throughout the nervous system. Sensory afferent feedback plays a crucial role in the rhythmical muscle activation pattern, as it affects through spinal reflex circuits the spinal neuronal networks responsible for inducing and maintaining rhythmicity, drives short-term and long-term re-organization of the brain and spinal cord circuits, and contributes to recovery of walking after locomotor training. Therefore, spinal circuits integrating sensory signals are adjustable networks with learning capabilities. In this review, I will synthesize the mechanisms underlying phase-dependent modulation of spinal reflexes in healthy humans as well as those with spinal or cerebral lesions along with findings on afferent regulation of spinal reflexes and central pattern generator in reduced animal preparations. Recovery of walking after locomotor training has been documented in numerous studies but the re-organization of spinal interneuronal and cortical circuits need to be further explored at cellular and physiological levels. For maximizing sensorimotor recovery in people with spinal or cerebral lesions, a multidisciplinary approach (rehabilitation, pharmacology, and electrical stimulation) delivered during various sensorimotor constraints is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.