ArticleBMC physiology2010
Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria.
Article in BMC physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Retention and tissue-specific expression of uncoupling protein homoeologs in Xenopus laevis.Biology open · 2026Article
- Incubation temperature shapes growth and mitochondrial metabolism across embryonic development in Japanese quail.Proceedings. Biological sciences · 2025Article
- Thermal challenge significantly alters gene expression in breast muscle of commercial turkey poults.Frontiers in physiology · 2025Article
- Embryonic thermal manipulation: a potential strategy to mitigate heat stress in broiler chickens for sustainable poultry production.Journal of animal science and biotechnology · 2024Review
- Whole-body endothermy: ancient, homologous and widespread among the ancestors of mammals, birds and crocodylians.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Article
- Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds.Frontiers in physiology · 2022Article
- In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments.Amino acids · 2021Article
- Regulation of gene expression in chickens by heat stress.Journal of animal science and biotechnology · 2021Review
- Testing the carotenoid-based sexual signalling mechanism by alteringProceedings. Biological sciences · 2020Article
- Thermal stress consequences on growth performance, immunological response, antioxidant status, and profitability of finishing broilers: transcriptomic profile change of stress-related genes.Tropical animal health and production · 2020Article
- Unraveling the Mystery of Cold Stress-Induced Myocardial Injury.Frontiers in physiology · 2020Review
- Lipid-induced thermogenesis is up-regulated by the first cold-water immersions in juvenile penguins.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- The 12-day thermoregulatory metamorphosis of Red-winged Blackbirds (Agelaius phoeniceus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Thermal stress induces changes in gene expression and blood parameters in high and low feed efficiency meat quail.Journal of applied genetics · 2015Article
- Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Growth prior to thermogenesis for a quick fledging of Adélie penguin chicks (Pygoscelis adeliae).PloS one · 2013Article
- Article
- Differential effects of thyroid status on regional H₂O₂ production in slow- and fast-twitch muscle of ducklings.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough identified in several bird species, the biological role of the avian homolog of mammalian uncoupling proteins (avUCP) remains extensively debated. In the present study, the functional properties of isolated mitochondria were examined in physiological or pharmacological situations that induce large changes in avUCP expression in duckling skeletal muscle.
resultsThe abundance of avUCP mRNA, as detected by RT-PCR in gastrocnemius muscle but not in the liver, was markedly increased by cold acclimation (CA) or pharmacological hyperthyroidism but was down-regulated by hypothyroidism. Activators of UCPs, such as superoxide with low doses of fatty acids, stimulated a GDP-sensitive proton conductance across the inner membrane of muscle mitochondria from CA or hyperthyroid ducklings. The stimulation was much weaker in controls and not observed in hypothyroid ducklings or in any liver mitochondrial preparations. The production of endogenous mitochondrial reactive oxygen species (ROS) was much lower in muscle mitochondria from CA and hyperthyroid ducklings than in the control or hypothyroid groups. The addition of GDP markedly increased the mitochondrial ROS production of CA or hyperthyroid birds up to, or above, the level of control or hypothyroid ducklings. Differences in ROS production among groups could not be attributed to changes in antioxidant enzyme activities (superoxide dismutase or glutathione peroxidase).
conclusionThis work provides the first functional in vitro evidence that avian UCP regulates mitochondrial ROS production in situations of enhanced metabolic activity.
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