ArticleBMC evolutionary biology2010
Non-random genomic integration - an intrinsic property of retrogenes in Drosophila?
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Peculiarities of theInternational journal of molecular sciences · 2025Article
- Genes Relocated Between Drosophila Chromosome Arms Evolve Under Relaxed Selective Constraints Relative to Non-Relocated Genes.Journal of molecular evolution · 2018Article
- Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes.BMC evolutionary biology · 2012Article
- Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Article
- Little evidence for demasculinization of the Drosophila X chromosome among genes expressed in the male germline.Genome biology and evolution · 2012Article
- Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster.Genome research · 2011Article
- Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation.PLoS biology · 2011Article
- Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome.BMC biology · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization). This trend is matched by retrogenes, which typically have a male biased gene expression pattern and show a significant movement bias from X-chromosomes to autosomes. It is currently assumed that these patterns are best explained by selection, either mediated by male meiotic sex chromosome inactivation (MSCI) or sexually antagonistic forces. We scrutinized the evolutionary dynamics of retroposition by focusing on retrogenes for which the parental copy has degenerated.
resultsConsistent with a functional substitution of the degenerated gene by the retrogene, patterns of sequence evolution and gene expression were similar between retroposed and parental genes. Like previous studies, our set of retrogenes showed a significant movement off the X-chromosome. In contrast to data sets where retroposition caused gene duplication, the genes in our study showed primarily female-biased or unbiased gene expression.
conclusionsBased on our results, the biased transposition pattern cannot be explained by MSCI and probably not by sexual antagonism. Rather, we propose that the movement away from the X-chromosome represents a general property of retroposition in Drosophila.
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