Evidence map›Paper›PMID 20426834›Full record

Trial reportCritical care (London, England)2010

Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial.

Christina Routsi, Vasiliki Gerovasili, Ioannis Vasileiadis, Eleftherios Karatzanos, Theodore Pitsolis, Elli Tripodaki, Vasiliki Markaki, Dimitrios Zervakis, Serafim Nanas

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 108 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00882830 phase2unknown statusnot on this map

Electrical Muscle Stimulation (EMS), a Preventive and Therapeutic Tool for Critical Illness Polyneuromyopathy (CIPNM)- A Randomized Controlled Parallel Intervention Trial.

TypeinterventionalSponsorUniversity of AthensRan2007 to 2015Enrolled52ConditionsCritical Illness Polyneuromyopathy (CIPNM), ICU Acquired Weakness (ICUAW)ArmsEMS
NCT02391103 nacompletednot on this mapstarted 2011, after this paper: background citation

Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery. An Ultrasound-Based Randomized Controlled Trial

TypeinterventionalSponsorMedical University of ViennaRan2011 to 2015Enrolled54ConditionsNeuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle LossArmsCompex 3 Professional (CefarCompex Medical AB) stimulator, sham-stimulation
NCT02566941 nawithdrawnnot on this mapstarted 2015, after this paper: background citation

Neuromuscular Electrical Stimulation in the Critically Ill

TypeinterventionalSponsorBrugmann University HospitalRan2015 to 2018Enrolled0ConditionsPolyneuropathyArmsGymna Belgium, DUO 400 (Neuromuscular electrical stimulation)
NCT02706587 phase3unknown statusnot on this mapstarted 2016, after this paper: background citation

Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness

TypeinterventionalSponsorInstitut Mutualiste MontsourisRan2016 to 2018Enrolled102ConditionsPolyneuropathy, Critical IllnessArmsNeuromuscular electrical stimulation, Sham control
NCT05536531 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Role of Neuromuscular Electrical Stimulation to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines Profile. A Randomized Clinical Trial.

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2022 to 2025Enrolled32ConditionsMuscle Weakness or Atrophy, Mechanical Ventilation Complication, Electrical StimulationsArmsNeuromuscular electrical stimulation (NMES)
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  12. Physical rehabilitation for critical illness myopathy and neuropathy.The Cochrane database of systematic reviews · 2015
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Christina RoutsiFirst Critical Care Department, National and Kapodistrian University of Athens Evangelismos Hospital, Ypsilantou 45-47, Athens, Greece. croutsi@hotmail.com
Vasiliki Gerovasili
Ioannis Vasileiadis
Eleftherios Karatzanos
Theodore Pitsolis
Elli Tripodaki
Vasiliki Markaki
Dimitrios Zervakis
Serafim Nanas

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCritical illness polyneuromyopathy (CIPNM) is a common complication of critical illness presenting with muscle weakness and is associated with increased duration of mechanical ventilation and weaning period. No preventive tool and no specific treatment have been proposed so far for CIPNM. Electrical muscle stimulation (EMS) has been shown to be beneficial in patients with severe chronic heart failure and chronic obstructive pulmonary disease. Aim of our study was to assess the efficacy of EMS in preventing CIPNM in critically ill patients.

methodsOne hundred and forty consecutive critically ill patients with an APACHE II score >or= 13 were randomly assigned after stratification to the EMS group (n = 68) (age:61 +/- 19 years) (APACHE II:18 +/- 4, SOFA:9 +/- 3) or to the control group (n = 72) (age:58 +/- 18 years) (APACHE II:18 +/- 5, SOFA:9 +/- 3). Patients of the EMS group received daily EMS sessions. CIPNM was diagnosed clinically with the medical research council (MRC) scale for muscle strength (maximum score 60, <48/60 cut off for diagnosis) by two unblinded independent investigators. Duration of weaning from mechanical ventilation and intensive care unit (ICU) stay were recorded.

resultsFifty two patients could be finally evaluated with MRC; 24 in the EMS group and 28 in the control group. CIPNM was diagnosed in 3 patients in the EMS group as compared to 11 patients in the control group (OR = 0.22; CI: 0.05 to 0.92, P = 0.04). The MRC score was significantly higher in patients of the EMS group as compared to the control group [58 (33 to 60) vs. 52 (2 to 60) respectively, median (range), P = 0.04). The weaning period was statistically significantly shorter in patients of the EMS group vs. the control group [1 (0 to 10) days vs. 3 (0 to 44) days, respectively, median (range), P = 0.003].

conclusionsThis study suggests that daily EMS sessions prevent the development of CIPNM in critically ill patients and also result in shorter duration of weaning. Further studies should evaluate which patients benefit more from EMS and explore the EMS characteristics most appropriate for preventing CIPNM. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT00882830.

Indexed as

Critical IllnessElectric StimulationAdultAgedAPACHEFemaleHumansIntensive Care UnitsMaleMiddle AgedMuscle, SkeletalPolyneuropathiesRespiration, Artificial

Identifiers

PMID20426834
PMCPMC2887197

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.