ArticleRespiratory research2010
Clinical patterns in asthma based on proximal and distal airway nitric oxide categories.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Fractional exhaled nitric oxide at multiple flow rates in chronic cough: association with lung function and airway hyperresponsiveness.Annals of medicine · 2026Article
- Reference values for exhaled nitric oxide in healthy children aged 6-18 years in China: a cross-sectional, multicenter clinical study.Respiratory research · 2024Article
- [Alveolar nitric oxide concentration has a potential value in the diagnosis and differential diagnosis of interstitial lung diseases].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Significance of alveolar nitric oxide concentration in the airway of patients with organizing pneumonia after allogeneic hematopoietic stem cell transplantation.Annals of hematology · 2022Article
- Small airway dysfunction and poor asthma control: a dangerous liaison.Clinical and molecular allergy : CMA · 2021Review
- Study of the role of exhaled nitric oxide (NO) in predicting controlled or uncontrolled asthma in asthmatic children.Multidisciplinary respiratory medicine · 2020Article
- Pulmonary Function Testing in Asthmatic Children. Tests to Assess Outpatients During the Covid-19 Pandemic.Frontiers in pediatrics · 2020Article
- Recent Advances in Inflammation and Treatment of Small Airways in Asthma.International journal of molecular sciences · 2019Review
- The Influence of 17 Hours of Normobaric Hypoxia on Parallel Adjustments in Exhaled Nitric Oxide and Airway Function in Lowland Healthy Adults.High altitude medicine & biology · 2017Article
- Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis.Pulmonary circulation · 2016Article
- An Overview of Fractional Exhaled Nitric Oxide and Children with Asthma.Expert review of clinical immunology · 2016Review
- Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease.The Journal of allergy and clinical immunology · 2015Article
- Small airway dysfunction and bronchial asthma control : the state of the art.Asthma research and practice · 2015Review
- Alveolar nitric oxide and its role in pediatric asthma control assessment.BMC pulmonary medicine · 2014Article
- Multiple-flow exhaled nitric oxide, allergy, and asthma in a population of older children.Pediatric pulmonology · 2013Article
- Physical deconditioning as a cause of breathlessness among obese adolescents with a diagnosis of asthma.PloS one · 2013Article
- Fractionated breath condensate sampling: H(2)O(2) concentrations of the alveolar fraction may be related to asthma control in children.Respiratory research · 2012Article
- Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO(2), CO and N(2)O) by infrared laser spectroscopy.Journal of breath research · 2011Article
- Elevated levels of NO are localized to distal airways in asthma.Free radical biology & medicine · 2011Article
- Exhaled nitric oxide and clinical phenotypes of childhood asthma.Respiratory research · 2011Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe exhaled nitric oxide (eNO) signal is a marker of inflammation, and can be partitioned into proximal [J'awNO (nl/s), maximum airway flux] and distal contributions [CANO (ppb), distal airway/alveolar NO concentration]. We hypothesized that J'awNO and CANO are selectively elevated in asthmatics, permitting identification of four inflammatory categories with distinct clinical features.
methodsIn 200 consecutive children with asthma, and 21 non-asthmatic, non-atopic controls, we measured baseline spirometry, bronchodilator response, asthma control and morbidity, atopic status, use of inhaled corticosteroids, and eNO at multiple flows (50, 100, and 200 ml/s) in a cross-sectional study design. A trumpet-shaped axial diffusion model of NO exchange was used to characterize J'awNO and CANO.
resultsJ'awNO was not correlated with CANO, and thus asthmatic subjects were grouped into four eNO categories based on upper limit thresholds of non-asthmatics for J'awNO (>or= 1.5 nl/s) and CANO (>or= 2.3 ppb): Type I (normal J'awNO and CANO), Type II (elevated J'awNO and normal CANO), Type III (elevated J'awNO and CANO) and Type IV (normal J'awNO and elevated CANO). The rate of inhaled corticosteroid use (lowest in Type III) and atopy (highest in Type II) varied significantly amongst the categories influencing J'awNO, but was not related to CANO, asthma control or morbidity. All categories demonstrated normal to near-normal baseline spirometry; however, only eNO categories with increased CANO (III and IV) had significantly worse asthma control and morbidity when compared to categories I and II.
conclusionsJ'awNO and CANO reveal inflammatory categories in children with asthma that have distinct clinical features including sensitivity to inhaled corticosteroids and atopy. Only categories with increase CANO were related to poor asthma control and morbidity independent of baseline spirometry, bronchodilator response, atopic status, or use of inhaled corticosteroids.
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