ArticleBMC research notes2010
Bioinformatic analysis of CaBP/calneuron proteins reveals a family of highly conserved vertebrate Ca2+-binding proteins.
Article in BMC research notes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Structure-Function Diversity of Calcium-Binding Proteins (CaBPs): Key Roles in Cell Signalling and Disease.Cells · 2025Review
- Calcium-Associated Proteins in Neuroregeneration.Biomolecules · 2024Review
- Regulation of Presynaptic Calcium Channels.Advances in neurobiology · 2023Article
- Transcriptome analysis revealed potential genes involved in thermogenesis in muscle tissue in cold-exposed lambs.Frontiers in genetics · 2022Article
- Mitosis, Focus on Calcium.Frontiers in physiology · 2022Review
- Calcium Sensors in Neuronal Function and Dysfunction.Cold Spring Harbor perspectives in biology · 2019Review
- Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model.Frontiers in bioengineering and biotechnology · 2016Article
- Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Sense and specificity in neuronal calcium signalling.Biochimica et biophysica acta · 2015Review
- Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells.Molecular biology of the cell · 2015Article
- Article
- Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.Investigative ophthalmology & visual science · 2013Article
- Article
- Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking.The Journal of biological chemistry · 2012Article
- Evolution and functional diversity of the Calcium Binding Proteins (CaBPs).Frontiers in molecular neuroscience · 2012Article
- Understanding the physiological roles of the neuronal calcium sensor proteins.Molecular brain · 2012Review
- Ca(2+) sensor proteins in dendritic spines: a race for Ca(2+).Frontiers in molecular neuroscience · 2012Article
- NCS-1 associates with adenosine A(2A) receptors and modulates receptor function.Frontiers in molecular neuroscience · 2012Article
- Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone.The Journal of biological chemistry · 2011Article
- Determination of the membrane topology of the small EF-hand Ca2+-sensing proteins CaBP7 and CaBP8.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCa2+-binding proteins are important for the transduction of Ca2+ signals into physiological outcomes. As in calmodulin many of the Ca2+-binding proteins bind Ca2+ through EF-hand motifs. Amongst the large number of EF-hand containing Ca2+-binding proteins are a subfamily expressed in neurons and retinal photoreceptors known as the CaBPs and the related calneuron proteins. These were suggested to be vertebrate specific but exactly which family members are expressed outside of mammalian species had not been examined.
findingsWe have carried out a bioinformatic analysis to determine when members of this family arose and the conserved aspects of the protein family. Sequences of human members of the family obtained from GenBank were used in Blast searches to identify corresponding proteins encoded in other species using searches of non-redundant proteins, genome sequences and mRNA sequences. Sequences were aligned and compared using ClustalW. Some families of Ca2+-binding proteins are known to show a progressive expansion in gene number as organisms increase in complexity. In contrast, the results for CaBPs and calneurons showed that a full complement of CaBPs and calneurons are present in the teleost fish Danio rerio and possibly in cartilaginous fish. These findings suggest that the entire family of genes may have arisen at the same time during vertebrate evolution. Certain members of the family (for example the short form of CaBP1 and calneuron 1) are highly conserved suggesting essential functional roles.
conclusionsThe findings support the designation of the calneurons as a distinct sub-family. While the gene number for CaBPs/calneurons does not increase, a distinctive evolutionary change in these proteins in vertebrates has been an increase in the number of splice variants present in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.