Evidence map›Paper›PMID 20426710›Full record

ReviewExpert opinion on pharmacotherapy2010

Amyloidosis and POEMS syndrome.

Cheng E Chee, Angela Dispenzieri, Morie A Gertz

Open access · greenAbstract readReview
In one paragraph

Review in Expert opinion on pharmacotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cheng E CheeDepartment of medicine, Mayo Clinic, Siebens 6, 200 SW First St, Rochester, MN 55905, USA.
Angela Dispenzieri
Morie A Gertz
Mayo Clinic · US

Funding

TISSUE BANK AND CLINICAL/LABORATORY DATABASEP01CA062242 · NCI · MAYO CLINIC ROCHESTER · PI FONSECAR, RAFAEL · 1994 to 2009
$12.9M
Prevalence and Progression of Monoclonal GammopathiesR01CA107476 · NCI · MAYO CLINIC ROCHESTER · PI KUMAR, SHAJI KUNNATHU, RAJKUMAR, S VINCENT · 2004 to 2018
$4.6M
Phase 3 stem cell transplant for light chain amyloidosisR01CA111345 · NCI · MAYO CLINIC ROCHESTER · PI GERTZ, MORIE ABRAHAM · 2005 to 2011
$1.4M
Virotherapy for Relapsed Refractory Multiple MyelomaR01CA125614 · NCI · MAYO CLINIC ROCHESTER · PI DISPENZIERI, ANGELA · 2006 to 2011
$1.2M
NCI NIH HHS CA107476NCI NIH HHS CA111345NCI NIH HHS CA125614NCI NIH HHS CA62242NCI NIH HHS P01 CA062242NCI NIH HHS R01 CA107476NCI NIH HHS R01 CA111345NCI NIH HHS R01 CA125614
6 · The paper itself

Abstract

importance of the fieldTreatment options for amyloidosis and polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome have rapidly increased in the past years, but many patients are diagnosed late in the disease course and do not receive state-of-the art therapy. AREAS COVERED IN THIS REVIEW: Stem-cell transplantation and novel agents have widened the chemotherapy alternatives available in these disorders and combinations of novel agents with high-dose therapy further improve treatment options. This review covers the main areas of debate in the optimal treatment amyloidosis and POEMS patients, focusing on the implications for everyday clinical practice and management strategies published in the past 36 months. WHAT THE READER WILL GAIN: Insights into treatment strategies are provided in the review. Keys to early recognition of the syndromes are reviewed. TAKE-HOME MESSAGE: With early diagnosis most patients are therapy candidates. New agents and new application of stem-cell transplantation have dramatically improved outcomes for these previously uniformly poor prognosis disorders.

Indexed as

Alkylating AgentsAmyloidosisDiagnosis, DifferentialHumansPOEMS SyndromePrognosisStem Cell TransplantationAlkylating Agents

Identifiers

PMID20426710
PMCPMC2874109
OpenAlexW2133241186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.