ArticleCurrent allergy and asthma reports2010
Update on infection and antibiotics in asthma.
Article in Current allergy and asthma reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Efficacy of Macrolides on Acute Asthma or Wheezing Exacerbations in Children with Recurrent Wheezing: A Systematic Review and Meta-analysis.Paediatric drugs · 2020Pooled it
- Antibiotics for exacerbations of asthma.The Cochrane database of systematic reviews · 2018Pooled it
- Risk Factors and Outcomes Associated With Antibiotic Therapy in Children Hospitalized With Asthma Exacerbation.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Treatment Protocol for COVID-19 Based on T2R Phenotype.Viruses · 2021Article
- Association ofExperimental and therapeutic medicine · 2017Article
- The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma-Food for Thought?Frontiers in immunology · 2017Review
- Airway Microbiota and the Implications of Dysbiosis in Asthma.Current allergy and asthma reports · 2016Review
- Effects of low-dose clarithromycin added to fluticasone on inflammatory markers and pulmonary function among children with asthma: A randomized clinical trial.Allergy & rhinology (Providence, R.I.) · 2016Article
- The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.Cell host & microbe · 2015Article
- Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosis.Science translational medicine · 2012Article
- Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases.European journal of clinical pharmacology · 2012Review
- Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics.Mediators of inflammation · 2012Review
- Current control and future risk in asthma management.Allergy, asthma & immunology research · 2011Article
- Lower respiratory tract infections in cats: reaching beyond empirical therapy.Journal of feline medicine and surgery · 2011Review
- Human T2R38 Bitter Taste Receptor Expression and COVID-19: From Immunity to Prognosis.Avicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma pathogenesis seems to be a result of a complex mixture of genetic and environmental influences. There is evidence that Mycoplasma pneumoniae and Chlamydophila pneumoniae (formerly known as Chlamydia pneumoniae) play a role in promoting airway inflammation that could contribute to the onset and clinical course of asthma. Evidence also indicates that when antimicrobial therapy can eradicate or suppress these organisms, it may be possible to alter the course of the disease. Certain macrolide antibiotics have been shown to improve control of asthma symptoms and lung function in patients diagnosed with acute C. pneumoniae or M. pneumoniae infection. Positive polymerase chain reaction studies for C. pneumoniae or M. pneumoniae are needed to select asthma patients for chronic treatment. Macrolide antibiotics may also have independent anti-inflammatory activity that may be useful in the management of asthma and other inflammatory diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.